Investigate the Effect of AZD1305 on Patients With Left Ventricular Dysfunction

A Single-centre, Single-blind, Randomised, Placebo-controlled Phase IIa Study to Investigate the Effect of AZD1305 Given as an Intravenous (iv) Infusion on Left Ventricular Performance in Patients With Left Ventricular Dysfunction

To explore if AZD1305 compromises left ventricular performance in patients with left ventricular dysfunction

Inclusion Criteria:

• Male patients and postmenopausal women
• Mildly/moderately decreased heart function
• Regular heart rhythm

Exclusion Criteria:

• Potassium outside normal reference values
• Child bearing potential
• Severely decreased heart function