Induced Angiogenesis by Genic Therapy in Advanced Ischemic Cardiomyopathy

Induced Angiogenesis by Genic Therapy With VEGF165 in Advanced Ischemic Cardiomyopathy - Historical Controlled Trial

Human Vascular Endothelial Grown Factor 165 (hVEGF165) administration is promising therapy induces a new vessels, arterioles and capillaries in regions whose revascularization surgery is not possible by direct or by percutaneous angioplasty. This study aims to evaluate the clinical effects and safety of gene therapy with hVEGF165 in patients with advanced coronary artery disease.

Inclusion Criteria:

• Diagnosis coronary artery disease and symptomatic, despite optimal pharmacologic therapy
• Left ventricular dysfunction - left ventricular ejection fraction between 60% and 25% by echocardiogram
• Non-conventional revascularization, as seen by cineangiocardiography, attested by interventional cardiologist and cardiac surgeon
• Age below 75 years
• Absence of neoplasm

Exclusion Criteria:

• No