Autologous Transplantation of Bone Marrow Mononuclear Stem-Cells for Dilated Cardiomyopathy

Autologous Transplantation of Bone Marrow Mononuclear Stem-Cells for Dilated Cardiomyopathy: Randomized Clinical Trial

This study describes a controlled randomized clinical trial to evaluate the efficacy of bone marrow derived stem-cell implants by minithoracotomy in patients with dilated cardiomyopathy and cardiac failure class III or NYHA.

Inclusion Criteria:

• Diagnosis made at more than one year and symptomatic at functional class III-IV by the New York Heart Association classification (NYHA) despite optimal pharmacologic therapy
• Left ventricular ejection fraction (LVEF) less than 35% by echocardiogram
• Age below 70 years
• Absence of neoplasm
• Abscence of hematologic disease or systemic disease
• No previous cardiac intervention

Exclusion Criteria:

• Episodes of tachycardia or ventricular fibrillation
• Severe or moderated mitral insufficiency
• Any other valvulopathies
• Previous cardiac surgery