Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population

Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population. The Paris Prospective Study III

The aim of the present Paris Prospective Study III (PPS3) is (1) to assess the determinants of the regulation of heart rate and blood pressure variations and carotid properties (under different physiologic stimulations) and (2) to evaluate the respective contribution of heart rate, blood pressure variations and carotid properties to cardiovascular morbidity and mortality including sudden death during 10 years at least in healthy considered subjects.

Overall, 10 157 men and women have been recruited during May 2008 and June 2012 for an extensive clinical examination including a 2h holter electrocardiography (ECG), a carotid doppler echo tracking, a step test, as well as blood and DNA collections. Since then, the cardiovascular morbidity and mortality of the participants is being followed up for 10 years at least and will continue up to 2032.

Inclusion Criteria:

• 50-75 years, French speaking, given consent for genetic analysis,
• written consent for participating in the study

Exclusion Criteria:

• <50 years and >75 years,
• no French speaking,
• current pregnancy,
• chronic severe disease,
• disagreement for genetic analysis,
• step test considered as non possible or non advisable by medical decision.