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| Name | Class |
|---|---|
| Turku Municipal Health Department/evo-funding | UNKNOWN |
| Turku University Hospital | OTHER_GOV |
| Finnsusp Ltd. | INDUSTRY |
| Aromtech Ltd. |
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The objective is to study the effect of sea buckthorn oil on dry eye.
The objective is to study whether regular consumption of sea buckthorn berry oil can relieve the symptoms of dry eye syndrome. The study design is a parallel randomized double-blind placebo controlled trial. The participants daily consume sea buckthorn or placebo oil for 3 months. The dry eye symptoms will be monitored during the study using a validated questionnaire. In addition clinical dry eye tests are made by an ophthalmologist three time during the study. Samples will be taken for tear film lipid and cytokine analyses. Blood samples for the analyses of inflammatory markers are also obtained. The cytokine and other inflammation marker analyses are optional. The symptoms will be monitored and clinical tests made also 4 weeks after the participants have stopped consuming the study oils.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SB | Experimental | Sea buckthorn oil group |
|
| PL | Placebo Comparator | Placebo group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sea buckthorn (Hippophaë rhamnoides) oil | Dietary Supplement | Dosage 2 g/d, frequency twice/d, duration 3 months |
|
| Measure | Description | Time Frame |
|---|---|---|
| Symptom severity: symptom questionnaires and clinical dry eye tests | 3 months intervention + 1 month after the intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Tear film lipid profile, tear cytokines, inflammation mediators in blood | 3 months intervention + 1 month after the intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Heikki P Kallio, Professor | University of Turku | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Turku | Turku | 20014 | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15539258 | Background | Yang B, Kalimo KO, Mattila LM, Kallio SE, Katajisto JK, Peltola OJ, Kallio HP. Effects of dietary supplementation with sea buckthorn (Hippophae rhamnoides) seed and pulp oils on atopic dermatitis. J Nutr Biochem. 1999 Nov;10(11):622-30. doi: 10.1016/s0955-2863(99)00049-2. | |
| 20554904 | Result | Larmo PS, Jarvinen RL, Setala NL, Yang B, Viitanen MH, Engblom JR, Tahvonen RL, Kallio HP. Oral sea buckthorn oil attenuates tear film osmolarity and symptoms in individuals with dry eye. J Nutr. 2010 Aug;140(8):1462-8. doi: 10.3945/jn.109.118901. Epub 2010 Jun 16. |
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| ID | Term |
|---|---|
| D015352 | Dry Eye Syndromes |
| ID | Term |
|---|---|
| D007766 | Lacrimal Apparatus Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D009821 | Oils |
| ID | Term |
|---|---|
| D008055 | Lipids |
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| INDUSTRY |
| Shiny Horse Ltd | UNKNOWN |
| Valioravinto Ltd | UNKNOWN |
| The Finnish Funding Agency for Technology and Innovation | OTHER_GOV |
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| Placebo comparison | Dietary Supplement | Placebo comparison, dosage 2 g/d, frequency twice/d, duration 3 months |
|