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This study is being conducted to examine the effect of AZD6140 on the levels of certain chemicals in subjects' blood and urine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental |
| |
| 2 | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AZD6140 | Drug | Oral tablets taken bid for 5 days |
| |
| Placebo to match AZD6140 |
| Measure | Description | Time Frame |
|---|---|---|
| The effect of AZD6140 on the levels of certain chemicals in subjects' blood and urine. | Levels or certain chemicals in subjects' blood and urine will be measured at scheduled times during the first 7 days of the study. |
| Measure | Description | Time Frame |
|---|---|---|
| The blood levels of AZD6140 in various subjects on the same diet. | following dosing during the first 5 days of the study | |
| The effect of taking AZD6140 on the levels of certain hormones in urine | during the first 5 days of the study |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kathleen Butler, MD | AstraZeneca | Study Director |
| Stuart Harris, MD | SeaView Research | Principal Investigator |
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| ID | Term |
|---|---|
| D006073 | Gout |
| D003324 | Coronary Artery Disease |
| D006356 | Heartburn |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D000070657 | Crystal Arthropathies |
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| ID | Term |
|---|---|
| D000077486 | Ticagrelor |
| ID | Term |
|---|---|
| D000241 | Adenosine |
| D011684 | Purine Nucleosides |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
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| Drug |
Oral tablets taken bid for 5 days |
|
| D012216 |
| Rheumatic Diseases |
| D011686 | Purine-Pyrimidine Metabolism, Inborn Errors |
| D008661 | Metabolism, Inborn Errors |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D000072471 |
| Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D009705 | Nucleosides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
| D012263 | Ribonucleosides |