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Omega-3 fatty acids are notably present in fish oil and krill oil, and are known to have beneficial effects on the vasculature. Vitamin K2 is known for preventing vascular calcification. In this study we investigate a potential synergy between the effects of either fish or krill oil and menaquinone-7, which is one of K2 vitamins.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | 9 fish oil capsules, equivalent to 3 gram per day of n-3 polyunsaturated fatty acids (PUFA) |
|
| 2 | Active Comparator | 9 fish oil capsules, equivalent to 3 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 1 capsule of menaquinone-7 per day (10 µg) |
|
| 3 | Active Comparator | 9 fish oil capsules, equivalent to 3 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 2 capsules of menaquinone-7 per day (20 µg per day) |
|
| 4 | Active Comparator | 9 fish oil capsules, equivalent to 3 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 1 capsule of menaquinone-7 per day (45 µg per day) |
|
| 5 | Active Comparator | 9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA) |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| menaquinone-7 | Dietary Supplement | capsule consisting of 10, 20 or 45 µg menaquinone-7 per day during 8 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Endogenous Thrombin Potential (ETP) | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Osteocalcin carboxylation | 12 weeks | |
| Matrix Gla-protein carboxylation | 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Cees Vermeer, PhD | Department of Biochemistry, Maastricht University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| VitaK - Maastricht University | Maastricht | 6200 MD | Netherlands |
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| ID | Term |
|---|---|
| D050197 | Atherosclerosis |
| D002114 | Calcinosis |
| ID | Term |
|---|---|
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| C062629 | menaquinone 7 |
| D005395 | Fish Oils |
| ID | Term |
|---|---|
| D009821 | Oils |
| D008055 | Lipids |
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| 6 | Active Comparator | 9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 1 capsule of menaquinone-7 per day (10 µg) |
|
| 7 | Active Comparator | 9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 2 capsules of menaquinone-7 per day (20 µg per day) |
|
| 8 | Active Comparator | 9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 1 capsule of menaquinone-7 per day (45 µg per day) |
|
|
| fish oil | Dietary Supplement | 9 fish oil capsules equivalent to 3 gram per day of n-3 polyunsaturated fatty acids during 12 weeks |
|
| krill oil | Dietary Supplement | 9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA) during 12 weeks |
|
| D002128 |
| Calcium Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |