This study examined the safety and effectiveness of long-term administration of mometasone nasal spray in patients with perennial allergic rhinitis. Patients received mometasone for 12 weeks plus an additional 12 weeks if patient agreed to continue. Dose of mometasone could be decreased or increased during the study based on patient's response.

Inclusion Criteria:

• Moderate to severe perennial allergic rhinitis, >16 years of age

Exclusion Criteria:

• Patients with coexisting tuberculous disease or lower respiratory tract infection and patients who have acute upper respiratory tract infection, acute pharyngolaryngitis, or acute tonsillitis judged by the investigator to require treatment
• Patients with coexisting infections or systemic mycosis for which there are no effective treatment
• Patients with coexisting mycosis in the nasal and paranasal cavities
• Patients who are judged to require prohibited concomitant drugs during the clinical study
• Patients who have experienced recent nasal septum ulcers, nasal surgery, or nasal trauma, which have not yet healed
• Patients with a history of hypersensitivity to steroids or mometasone furoate
• Patients who are pregnant or nursing or who may be pregnant and patients or whose partner desires to become pregnant during the study period
• Patients with severe hepatic disorder, renal disorder, cardiac disease, diabetes mellitus, hypertension, or hematological disease or other serious coexisting diseases and whose general condition is poor as judged by the investigators.
• Patients allergic to pollen and the pollen release season occurs in the 7 days before the start of treatment
• Patients diagnosed with vasomotor rhinitis or eosinophilic rhinitis
• Patients with nasal conditions which may interfere with efficacy evaluation of the study drug
• Patients who develop a disease which may affect nasal symptoms in the 7 days before the start of treatment
• Patients who are participating or have participated in a clinical trial of an investigational drug within 120 days before the day of obtaining informed consent
• Patients for whom the period of discontinuation of previous treatment before the start of study drug administration indicated Table 2 is not adequate or who cannot avoid the use of these drugs
• Patients undergoing specific desensitization therapy or nonspecific allassotherapy (Histaglobin, vaccine therapy, etc.) or who had discontinued such therapy within 90 days prior to obtaining informed consent. (However, patients need not be excluded if therapy has been ongoing for at least 180 days before obtaining informed consent and maintenance therapy is now being conducted.)