This study aims to evaluate whether applying inflow vascular occlusion in modern liver resection is associated with better clinical outcome.

Eligible patients are randomly assigned to the two surgical techniques: with or without the application of inflow vascular occlusion.

Patients outcome including liver function recovery, operative time and blood loss are compared.

Inclusion Criteria:

• Age > 18 years
• Child-Pugh Class A or B

Exclusion Criteria:

• Informed consent not available
• Presence of portal vein thrombosis, portal vein tumor thrombus, or previous portal vein embolisation
• Presence of hepatic artery thrombosis, previous transarterial therapy like TACE, or transarterial internal radiation
• When portal vein resection is anticipated
• Emergency hepatectomy
• Ruptured hepatocellular carcinoma
• Rehepatectomy (repeated liver resection)
• Adhesion or anatomical variation that preclude safe and successful application of Pringle maneuver
• When concomitant bowel or bile duct resection is anticipated