Study on Clinical Outcome of Vascular Inflow Occlusion in Open Liver Resection

Open Liver Resection With or Without Vascular Inflow Occlusion: a Randomized Control Trial

This study aims to evaluate whether applying inflow vascular occlusion in modern liver resection is associated with better clinical outcome.

Eligible patients are randomly assigned to the two surgical techniques: with or without the application of inflow vascular occlusion.

Patients outcome including liver function recovery, operative time and blood loss are compared.

Inclusion Criteria:

• Age > 18 years
• Child-Pugh Class A or B

Exclusion Criteria:

• Informed consent not available
• Presence of portal vein thrombosis, portal vein tumor thrombus, or previous portal vein embolisation
• Presence of hepatic artery thrombosis, previous transarterial therapy like TACE, or transarterial internal radiation
• When portal vein resection is anticipated
• Emergency hepatectomy
• Ruptured hepatocellular carcinoma
• Rehepatectomy (repeated liver resection)
• Adhesion or anatomical variation that preclude safe and successful application of Pringle maneuver
• When concomitant bowel or bile duct resection is anticipated