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Assess the elimination of PD-0332334 from the blood with hemodialysis
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PD-0332334 | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PD-0332334 | Drug | A single, 50 mg oral dose (2 capsules) of PD-0332334 will be administered to each hemodialysis subject |
|
| Measure | Description | Time Frame |
|---|---|---|
| Maximum plasma concentration (Cmax) of PD-0332334 and time of maximum plasma concentration (Tmax). Half-life of PD-0332334 in this patient population with hemodialysis and without hemodialysis | 0 to 8 days | |
| Hemodialysis clearance of PD-0332334 from the blood, the total amount and fraction of total dose of PD-0332334 removed from the blood via hemodialysis, and the half-life of drug removal from the blood via hemodialysis | 0 to 8 days | |
| Area under the curve (AUC) of PD-0332334 from time of study medication administration to infinity (AUCinf); AUC of PD-0332334 from time of study medication administration to last quantifiable plasma concentration (AUClast). | 0 to 8 days |
| Measure | Description | Time Frame |
|---|---|---|
| Assess adverse events, findings from physical examinations, clinical safety laboratory assessments, ECG, vital signs. | 0 to 8 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pfizer CT.gov Call Center | Pfizer | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pfizer Investigational Site | Orlando | Florida | 32809 | United States |
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| Label | URL |
|---|---|
| To obtain contact information for a study center near you, click here. | View source |
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| ID | Term |
|---|---|
| C583768 | imagabalin |
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