A comparative bioavailability study of PCA slow release versus immediate release formulations, after a single dose to fasting healthy subjects.

Inclusion Criteria:

• Subjects who have completed the informed consent process culminating with written informed consent by the subject.

• Males

• Age 18-45 years

• Abstinence from alcohol for 1 week prior to the study

• Non smoking

• BMI > 19 and < 30

• No history or evidence of significant

  • cardiovascular,
  • hepatic,
  • renal,
  • hematopoietic,
  • gastrointestinal disease,
  • endocrine,
  • metabolic,
  • psychiatric
  • psychological disorders

• Normal physical examination

• Within +/- 10% of normal values in laboratory examinations

Exclusion Criteria:

• Subjects who suffer from a current medical condition.
• Subjects who smoke.
• Subjects who drink > 20 grams of alcohol per day.
• Subjects who take prescription medication.
• Subjects with an abnormality in screening blood tests
• Known sensitivity to any ingredients in the study drug