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| ID | Type | Description | Link |
|---|---|---|---|
| EudraCT 2008-000147-34 | |||
| IND 74863 |
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| Name | Class |
|---|---|
| Biogen | INDUSTRY |
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Comparison of the effects of different CDP323 doses given over a period of four weeks on blood biomarkers in subjects with relapsing forms of multiple sclerosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental |
| |
| 2 | Experimental |
| |
| 3 | Experimental |
| |
| 4 | Experimental |
| |
| 5 | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CDP323 | Drug | 50mg capsules, 100mg bid for 4 weeks |
| |
| CDP323 |
| Measure | Description | Time Frame |
|---|---|---|
| Pharmacodynamic parameters related to leukocyte trafficking | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Standard and disease-related safety variables | 4 weeks | |
| Class-related safety parameters | 4 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| UCB Clinical Trial Call Center | UCB Pharma | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tooting | London | United Kingdom | ||||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23472197 | Derived | Wolf C, Sidhu J, Otoul C, Morris DL, Cnops J, Taubel J, Bennett B. Pharmacodynamic consequences of administration of VLA-4 antagonist CDP323 to multiple sclerosis subjects: a randomized, double-blind phase 1/2 study. PLoS One. 2013;8(3):e58438. doi: 10.1371/journal.pone.0058438. Epub 2013 Mar 5. |
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| ID | Term |
|---|---|
| C584644 | CDP323 |
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| Drug |
250mg capsules, 500mg bid for 4 weeks |
|
| CDP323 | Drug | 250mg capsules, 1000mg bid for 4 weeks |
|
| CDP323 | Drug | 250mg capsules, 1000mg daily for 4 weeks |
|
| Placebo | Drug | placebo capsules for 4 weeks |
|
| Croydon |
| Surrey |
| United Kingdom |