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The objective of the study is to assess the safety and effectiveness of the Resolute Zotarolimus-Eluting Coronary Stent System for the treatment of de novo lesions in native coronary arteries with a reference vessel diameter (RVD) of 2.25 mm to 4.2 mm.
The trial is comprised of four studies: the 2.25 mm - 3.5 mm main study (1242 patients), the 2.25 mm - 3.5 mm Angio/IVUS sub-study (100 patients), the 4.0 mm sub-study (60 patients), and the 38 mm Length Sub-study (114 patients). A patient's inclusion in a given study is dependent on the size (diameter or length) of the stent(s) the patient receives.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Resolute Zotarolimus-Eluting Coronary Stent | Experimental | Implantation of a Resolute Zotarolimus-Eluting Coronary Stent |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resolute Zotarolimus-Eluting Coronary Stent | Device | Implantation of a Resolute Zotarolimus-Eluting Coronary Stent |
|
| Measure | Description | Time Frame |
|---|---|---|
| Target Lesion Failure (TLF) | Target Lesion Failure (TLF) at 12 months post-procedure, defined as Cardiac Death, Target Vessel Myocardial Infarction (TVMI) (Q wave and non-Q wave) or clinically-driven Target Lesion Revascularization (TLR) by percutaneous or surgical methods. | 12 Months |
| Measure | Description | Time Frame |
|---|---|---|
| Target Vessel Failure (TVF) | Target Vessel Failure (TVF) composite endpoint and each individual component (Cardiac Death, Target Vessel MI, or clinically-driven Target Vessel Revascularization (TVR) by percutaneous or surgical methods). | 12 months |
| Major Adverse Cardiac Event (MACE) |
Not provided
General and Angiographic Inclusion Criteria highlights:
General and Angiographic Exclusion Criteria highlights:
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| Name | Affiliation | Role |
|---|---|---|
| Martin B Leon, MD | Columbia University College of Physicians & Surgeons | Principal Investigator |
| Laura Mauri, MD, MSc | Brigham and Women's Hospital | Principal Investigator |
| Alex C Yeung, MD | Stanford University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| East Texas Medical Center | Tyler | Texas | 75701 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24510638 | Derived | Silber S, Kirtane AJ, Belardi JA, Liu M, Brar S, Rothman M, Windecker S. Lack of association between dual antiplatelet therapy use and stent thrombosis between 1 and 12 months following resolute zotarolimus-eluting stent implantation. Eur Heart J. 2014 Aug 1;35(29):1949-56. doi: 10.1093/eurheartj/ehu026. Epub 2014 Feb 7. | |
| 23523454 |
| Label | URL |
|---|---|
| Medtronic Home Page | View source |
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| ID | Title | Description |
|---|---|---|
| FG000 | Primary Enrollment Group | All patients may have one or two lesions, if the two lesions are located in separate coronary arteries. Patients were assigned in to one of four sub-studies based on the stent required: 2.25 mm - 3.5 mm Main study, 2.25 mm - 3.5 mm Angio/IVUS Sub-study, 4.0 mm Sub-study, or 38 mm Length Sub-study. Patients enrolled in the 2.25 - 3.5 mm Main Study, the 2.25 mm - 3.5 mm Angio/IVUS Sub-study, and the 4.0 mm Sub-study are collectively referred to as the Primary Enrollment Group (PEG). |
| FG001 | 38 mm Length Sub-study | All patients may have one or two lesions, if the two lesions are located in separate coronary arteries. Patients were assigned in to one of four sub-studies based on the stent required this group is the 38 mm Length Main study. Enrollment in this group opened after the Primary Enrollment Group had closed. |
| Title | Milestones | Reasons Not Completed | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary Enrollment Group |
|
| |||||||||||||||||||||
| 38 mm Length Group |
|
Not provided
Not provided
| ID | Title | Description |
|---|---|---|
| BG000 | Primary Enrollment Group | All patients may have one or two lesions, if the two lesions are located in separate coronary arteries. Patients were assigned in to one of four sub-studies based on the stent required: 2.25 mm - 3.5 mm Main study, 2.25 mm - 3.5 mm Angio/IVUS Sub-study, 4.0 mm Sub-study, or 38 mm Length Sub-study. Patients enrolled in the 2.25 - 3.5 mm Main Study, the 2.25 mm - 3.5 mm Angio/IVUS Sub-study, and the 4.0 mm Sub-study are collectively referred to as the Primary Enrollment Group (PEG). |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Target Lesion Failure (TLF) | Target Lesion Failure (TLF) at 12 months post-procedure, defined as Cardiac Death, Target Vessel Myocardial Infarction (TVMI) (Q wave and non-Q wave) or clinically-driven Target Lesion Revascularization (TLR) by percutaneous or surgical methods. | Posted | Number | percentage of participants | 12 Months |
|
12 months
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Primary Enrollment Group | All patients may have one or two lesions, if the two lesions are located in separate coronary arteries. Patients were assigned in to one of four sub-studies based on the stent required: 2.25 mm - 3.5 mm Main study, 2.25 mm - 3.5 mm Angio/IVUS Sub-study, 4.0 mm Sub-study and are collectively referred to as the Primary Enrollment Group (PEG). |
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Anaemia | Blood and lymphatic system disorders |
| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Angina Pectoris | Cardiac disorders |
Not provided
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| K. Bogdanovich | Medtronic Vascular | rs.medtroniccardiovascularclinicaltrials@medtronic.com |
Not provided
| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| D009203 | Myocardial Infarction |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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Major Adverse Cardiac Event (MACE) composite endpoint and each individual component (death, Target Vessel MI (Q wave and non-Q wave), emergent coronary bypass surgery (CABG), or clinically-driven repeat Target Lesion Revascularization (TLR) by percutaneous or surgical methods). |
| 12 months |
| Death | 12 months |
| Target Vessel MI | Target Vessel MI (as determined by extended historical and ARC definitions). | 12 months |
| Stent Thrombosis (ST) | Stent Thrombosis (ST) (as determined by historic and ARC definitions). | 12 months |
| Silber S, Serruys PW, Leon MB, Meredith IT, Windecker S, Neumann FJ, Belardi J, Widimsky P, Massaro J, Novack V, Yeung AC, Saito S, Mauri L. Clinical outcome of patients with and without diabetes mellitus after percutaneous coronary intervention with the resolute zotarolimus-eluting stent: 2-year results from the prospectively pooled analysis of the international global RESOLUTE program. JACC Cardiovasc Interv. 2013 Apr;6(4):357-68. doi: 10.1016/j.jcin.2012.11.006. Epub 2013 Mar 20. |
| 23468513 | Derived | Farooq V, Vranckx P, Mauri L, Cutlip DE, Belardi J, Silber S, Widimsky P, Leon M, Windecker S, Meredith I, Negoita M, van Leeuwen F, Neumann FJ, Yeung AC, Garcia-Garcia HM, Serruys PW. Impact of overlapping newer generation drug-eluting stents on clinical and angiographic outcomes: pooled analysis of five trials from the international Global RESOLUTE Program. Heart. 2013 May;99(9):626-33. doi: 10.1136/heartjnl-2012-303368. Epub 2013 Mar 6. |
| 21570508 | Derived | Mauri L, Leon MB, Yeung AC, Negoita M, Keyes MJ, Massaro JM. Rationale and design of the clinical evaluation of the Resolute Zotarolimus-Eluting Coronary Stent System in the treatment of de novo lesions in native coronary arteries (the RESOLUTE US clinical trial). Am Heart J. 2011 May;161(5):807-14. doi: 10.1016/j.ahj.2011.03.015. Epub 2011 Mar 29. |
| 21470813 | Derived | Yeung AC, Leon MB, Jain A, Tolleson TR, Spriggs DJ, Mc Laurin BT, Popma JJ, Fitzgerald PJ, Cutlip DE, Massaro JM, Mauri L; RESOLUTE US Investigators. Clinical evaluation of the Resolute zotarolimus-eluting coronary stent system in the treatment of de novo lesions in native coronary arteries: the RESOLUTE US clinical trial. J Am Coll Cardiol. 2011 Apr 26;57(17):1778-83. doi: 10.1016/j.jacc.2011.03.005. Epub 2011 Apr 4. |
| Medtronic Clinical Trials Link | View source |
| NOT COMPLETED |
|
|
| BG001 | 38 mm Length Sub-study | All patients may have one or two lesions, if the two lesions are located in separate coronary arteries. Patients were assigned in to one of four sub-studies based on the stent required this group is the 38 mm Length Main study. Enrollment in this group opened after the Primary Enrollment Group had closed. This sub-study completed the primary endpoint in March 2012 results not yet available. |
| BG002 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
| Units | Counts |
|---|---|
| Participants |
|
|
| Secondary | Target Vessel Failure (TVF) | Target Vessel Failure (TVF) composite endpoint and each individual component (Cardiac Death, Target Vessel MI, or clinically-driven Target Vessel Revascularization (TVR) by percutaneous or surgical methods). | Posted | Number | percentage of participants | 12 months |
|
|
|
| Secondary | Major Adverse Cardiac Event (MACE) | Major Adverse Cardiac Event (MACE) composite endpoint and each individual component (death, Target Vessel MI (Q wave and non-Q wave), emergent coronary bypass surgery (CABG), or clinically-driven repeat Target Lesion Revascularization (TLR) by percutaneous or surgical methods). | Posted | Number | percentage of participants | 12 months |
|
|
|
| Secondary | Death | Posted | Number | percentage of participants | 12 months |
|
|
|
| Secondary | Target Vessel MI | Target Vessel MI (as determined by extended historical and ARC definitions). | Posted | Number | percentage of eligible participants | 12 months |
|
|
|
| Secondary | Stent Thrombosis (ST) | Stent Thrombosis (ST) (as determined by historic and ARC definitions). | Posted | Number | percentage of participants | 12 months |
|
|
|
| 509 |
| 1,402 |
| 724 |
| 1,402 |
| EG001 | 38 mm Length Sub-Study | All patients may have one or two lesions, if the two lesions are located in separate coronary arteries. Patients were assigned in to one of four sub-studies based on the stent required this group is the 38 mm Length Main study. Enrollment in this group opened after the Primary Enrollment Group had closed. | 71 | 114 | 67 | 114 |
| Coagulopathy | Blood and lymphatic system disorders |
|
| Disseminated Intravascular Coagulation | Blood and lymphatic system disorders |
|
| Leukocytosis | Blood and lymphatic system disorders |
|
| Lymphadenopathy | Blood and lymphatic system disorders |
|
| Acute Coronary Syndrome | Cardiac disorders |
|
| Acute Myocardial Infarction | Cardiac disorders |
|
| Angina Pectoris | Cardiac disorders |
|
| Angina Unstable | Cardiac disorders |
|
| Aortic Valve Stenosis | Cardiac disorders |
|
| Arrhythmia | Cardiac disorders |
|
| Arteriospasm Coronary | Cardiac disorders |
|
| Atrial Fibrillation | Cardiac disorders |
|
| Atrial Flutter | Cardiac disorders |
|
| Atrioventricular Block Complete | Cardiac disorders |
|
| Bradycardia | Cardiac disorders |
|
| Cardiac Arrest | Cardiac disorders |
|
| Cardiac Failure | Cardiac disorders |
|
| Cardiac Failure Congestive | Cardiac disorders |
|
| Cardiac Valve Disease | Cardiac disorders |
|
| Cardio-Respiratory Arrest | Cardiac disorders |
|
| Cardiogenic Shock | Cardiac disorders |
|
| Coronary Artery Disease | Cardiac disorders |
|
| Coronary Artery Dissection | Cardiac disorders |
|
| Coronary Artery Embolism | Cardiac disorders |
|
| Coronary Artery Occlusion | Cardiac disorders |
|
| Coronary Artery Perforation | Cardiac disorders |
|
| Coronary Artery Restenosis | Cardiac disorders |
|
| Coronary Artery Stenosis | Cardiac disorders |
|
| In-Stent Coronary Artery Restenosis | Cardiac disorders |
|
| Ischaemic Cardiomyopathy | Cardiac disorders |
|
| Myocardial Infarction | Cardiac disorders |
|
| Myocardial Ischaemia | Cardiac disorders |
|
| Palpitations | Cardiac disorders |
|
| Pericarditis | Cardiac disorders |
|
| Sick Sinus Syndrome | Cardiac disorders |
|
| Supraventricular Tachycardia | Cardiac disorders |
|
| Tachycardia | Cardiac disorders |
|
| Ventricular Arrhythmia | Cardiac disorders |
|
| Ventricular Fibrillation | Cardiac disorders |
|
| Ventricular Tachycardia | Cardiac disorders |
|
| Arteriovenous Malformation | Congenital, familial and genetic disorders |
|
| Atrial Septal Defect | Congenital, familial and genetic disorders |
|
| Vertigo | Ear and labyrinth disorders |
|
| Hyperparathyroidism Primary | Endocrine disorders |
|
| Amaurosis Fugax | Eye disorders |
|
| Cataract | Eye disorders |
|
| Conjunctivitis | Eye disorders |
|
| Eye Swelling | Eye disorders |
|
| Abdominal Pain | Gastrointestinal disorders |
|
| Abdominal Pain Upper | Gastrointestinal disorders |
|
| Barrett's Oesophagus | Gastrointestinal disorders |
|
| Colitis | Gastrointestinal disorders |
|
| Colitis Ischaemic | Gastrointestinal disorders |
|
| Constipation | Gastrointestinal disorders |
|
| Diarrhoea | Gastrointestinal disorders |
|
| Dyspepsia | Gastrointestinal disorders |
|
| Gastritis | Gastrointestinal disorders |
|
| Gastrointestinal Haemorrhage | Gastrointestinal disorders |
|
| Gastrooesophageal Reflux Disease | Gastrointestinal disorders |
|
| Haematemesis | Gastrointestinal disorders |
|
| Hiatus Hernia | Gastrointestinal disorders |
|
| Ileus | Gastrointestinal disorders |
|
| Intestinal Ischaemia | Gastrointestinal disorders |
|
| Intestinal Obstruction | Gastrointestinal disorders |
|
| Large Intestinal Haemorrhage | Gastrointestinal disorders |
|
| Large Intestine Perforation | Gastrointestinal disorders |
|
| Pancreatitis | Gastrointestinal disorders |
|
| Pancreatitis Acute | Gastrointestinal disorders |
|
| Pancreatitis Chronic | Gastrointestinal disorders |
|
| Pancreatitis Necrotising | Gastrointestinal disorders |
|
| Rectal Haemorrhage | Gastrointestinal disorders |
|
| Retroperitoneal Haemorrhage | Gastrointestinal disorders |
|
| Small Intestinal Obstruction | Gastrointestinal disorders |
|
| Splenic Artery Aneurysm | Gastrointestinal disorders |
|
| Vomiting | Gastrointestinal disorders |
|
| Adverse Drug Reaction | General disorders |
|
| Asthenia | General disorders |
|
| Catheter Site Haemorrhage | General disorders |
|
| Chest Discomfort | General disorders |
|
| Chest Pain | General disorders |
|
| Death | General disorders |
|
| Fatigue | General disorders |
|
| Granuloma | General disorders |
|
| Hernia | General disorders |
|
| Implant Site Effusion | General disorders |
|
| Injection Site Haematoma | General disorders |
|
| Injection Site Haemorrhage | General disorders |
|
| Mass | General disorders |
|
| Multi-Organ Failure | General disorders |
|
| Non-Cardiac Chest Pain | General disorders |
|
| Pain | General disorders |
|
| Systemic Inflammatory Response Syndrome | General disorders |
|
| Biliary Colic | Hepatobiliary disorders |
|
| Cholangitis | Hepatobiliary disorders |
|
| Cholecystitis | Hepatobiliary disorders |
|
| Cholecystitis Acute | Hepatobiliary disorders |
|
| Cholelithiasis | Hepatobiliary disorders |
|
| Cholestasis | Hepatobiliary disorders |
|
| Gallbladder Disorder | Hepatobiliary disorders |
|
| Hepatic Failure | Hepatobiliary disorders |
|
| Ischaemic Hepatitis | Hepatobiliary disorders |
|
| Anaphylactic Reaction | Immune system disorders |
|
| Hypersensitivity | Immune system disorders |
|
| Abscess Limb | Infections and infestations |
|
| Abscess Neck | Infections and infestations |
|
| Appendicitis | Infections and infestations |
|
| Bronchitis | Infections and infestations |
|
| Bronchopneumonia | Infections and infestations |
|
| Catheter Site Infection | Infections and infestations |
|
| Cellulitis | Infections and infestations |
|
| Cellulitis Staphylococcal | Infections and infestations |
|
| Clostridial Infection | Infections and infestations |
|
| Clostridium Difficile Colitis | Infections and infestations |
|
| Diverticulitis | Infections and infestations |
|
| Endocarditis Bacterial | Infections and infestations |
|
| Escherichia Bacteraemia | Infections and infestations |
|
| Gastroenteritis | Infections and infestations |
|
| Gastroenteritis Viral | Infections and infestations |
|
| Infection | Infections and infestations |
|
| Liver Abscess | Infections and infestations |
|
| Perirectal Abscess | Infections and infestations |
|
| Pneumonia | Infections and infestations |
|
| Pyelonephritis | Infections and infestations |
|
| Sepsis | Infections and infestations |
|
| Septic Shock | Infections and infestations |
|
| Staphylococcal Bacteraemia | Infections and infestations |
|
| Staphylococcal Infection | Infections and infestations |
|
| Syphilitic Endocarditis Of Heart Valve | Infections and infestations |
|
| Urinary Tract Infection | Infections and infestations |
|
| Ankle Fracture | Injury, poisoning and procedural complications |
|
| Arteriovenous Graft Thrombosis | Injury, poisoning and procedural complications |
|
| Contusion | Injury, poisoning and procedural complications |
|
| Excoriation | Injury, poisoning and procedural complications |
|
| Hand Fracture | Injury, poisoning and procedural complications |
|
| Injury | Injury, poisoning and procedural complications |
|
| Meniscus Lesion | Injury, poisoning and procedural complications |
|
| Multiple Fractures | Injury, poisoning and procedural complications |
|
| Overdose | Injury, poisoning and procedural complications |
|
| Road Traffic Accident | Injury, poisoning and procedural complications |
|
| Spinal Fracture | Injury, poisoning and procedural complications |
|
| Stent Occlusion | Injury, poisoning and procedural complications |
|
| Sternal Fracture | Injury, poisoning and procedural complications |
|
| Subdural Haematoma | Injury, poisoning and procedural complications |
|
| Therapeutic Agent Toxicity | Injury, poisoning and procedural complications |
|
| Thrombosis In Device | Injury, poisoning and procedural complications |
|
| Upper Limb Fracture | Injury, poisoning and procedural complications |
|
| Urethral Injury | Injury, poisoning and procedural complications |
|
| Blood Creatine Phosphokinase Mb Increased | Investigations |
|
| Blood Creatinine Increased | Investigations |
|
| Blood Glucose Increased | Investigations |
|
| Cardiac Enzymes Increased | Investigations |
|
| Cardiac Stress Test Abnormal | Investigations |
|
| Ejection Fraction Decreased | Investigations |
|
| Troponin T Increased | Investigations |
|
| Dehydration | Metabolism and nutrition disorders |
|
| Diabetes Mellitus Inadequate Control | Metabolism and nutrition disorders |
|
| Fluid Overload | Metabolism and nutrition disorders |
|
| Hypercalcaemia | Metabolism and nutrition disorders |
|
| Hyperglycaemia | Metabolism and nutrition disorders |
|
| Hyperkalaemia | Metabolism and nutrition disorders |
|
| Hypoglycaemia | Metabolism and nutrition disorders |
|
| Hyponatraemia | Metabolism and nutrition disorders |
|
| Hypovolaemia | Metabolism and nutrition disorders |
|
| Metabolic Acidosis | Metabolism and nutrition disorders |
|
| Obesity | Metabolism and nutrition disorders |
|
| Arthralgia | Musculoskeletal and connective tissue disorders |
|
| Arthritis | Musculoskeletal and connective tissue disorders |
|
| Arthropathy | Musculoskeletal and connective tissue disorders |
|
| Back Pain | Musculoskeletal and connective tissue disorders |
|
| Bone Lesion | Musculoskeletal and connective tissue disorders |
|
| Flank Pain | Musculoskeletal and connective tissue disorders |
|
| Intervertebral Disc Protrusion | Musculoskeletal and connective tissue disorders |
|
| Muscular Weakness | Musculoskeletal and connective tissue disorders |
|
| Musculoskeletal Chest Pain | Musculoskeletal and connective tissue disorders |
|
| Musculoskeletal Pain | Musculoskeletal and connective tissue disorders |
|
| Osteoarthritis | Musculoskeletal and connective tissue disorders |
|
| Pain In Extremity | Musculoskeletal and connective tissue disorders |
|
| Pain In Jaw | Musculoskeletal and connective tissue disorders |
|
| Spinal Osteoarthritis | Musculoskeletal and connective tissue disorders |
|
| Bladder Cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Brain Neoplasm | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Breast Cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Bronchioloalveolar Carcinoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Choroid Melanoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Colon Cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Lung Adenocarcinoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Lung Neoplasm | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Lung Neoplasm Malignant | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Lymphoma | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Metastatic Neoplasm | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Myelodysplastic Syndrome | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Myeloproliferative Disorder | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Prostate Cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Prostate Cancer Metastatic | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Renal Cell Carcinoma Stage Unspecified | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Small Cell Lung Cancer Stage Unspecified | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Tongue Neoplasm Malignant Stage Unspecified | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Tonsil Cancer | Neoplasms benign, malignant and unspecified (incl cysts and polyps) |
|
| Carotid Artery Stenosis | Nervous system disorders |
|
| Cerebral Haemorrhage | Nervous system disorders |
|
| Cerebrovascular Accident | Nervous system disorders |
|
| Cervical Myelopathy | Nervous system disorders |
|
| Dizziness | Nervous system disorders |
|
| Encephalopathy | Nervous system disorders |
|
| Haemorrhage Intracranial | Nervous system disorders |
|
| Headache | Nervous system disorders |
|
| Hydrocephalus | Nervous system disorders |
|
| Hypoaesthesia | Nervous system disorders |
|
| Lethargy | Nervous system disorders |
|
| Nerve Compression | Nervous system disorders |
|
| Presyncope | Nervous system disorders |
|
| Syncope | Nervous system disorders |
|
| Syncope Vasovagal | Nervous system disorders |
|
| Transient Ischaemic Attack | Nervous system disorders |
|
| Anxiety | Psychiatric disorders |
|
| Completed Suicide | Psychiatric disorders |
|
| Confusional State | Psychiatric disorders |
|
| Mental Status Changes | Psychiatric disorders |
|
| Bladder Neck Sclerosis | Renal and urinary disorders |
|
| Bladder Obstruction | Renal and urinary disorders |
|
| Haematuria | Renal and urinary disorders |
|
| Haemorrhage Urinary Tract | Renal and urinary disorders |
|
| Nephrolithiasis | Renal and urinary disorders |
|
| Nephrotic Syndrome | Renal and urinary disorders |
|
| Renal Artery Stenosis | Renal and urinary disorders |
|
| Renal Failure | Renal and urinary disorders |
|
| Renal Failure Acute | Renal and urinary disorders |
|
| Renal Mass | Renal and urinary disorders |
|
| Uterine Haemorrhage | Reproductive system and breast disorders |
|
| Uterine Prolapse | Reproductive system and breast disorders |
|
| Acute Respiratory Distress Syndrome | Respiratory, thoracic and mediastinal disorders |
|
| Acute Respiratory Failure | Respiratory, thoracic and mediastinal disorders |
|
| Asthma | Respiratory, thoracic and mediastinal disorders |
|
| Chronic Obstructive Pulmonary Disease | Respiratory, thoracic and mediastinal disorders |
|
| Cough | Respiratory, thoracic and mediastinal disorders |
|
| Dyspnoea | Respiratory, thoracic and mediastinal disorders |
|
| Dyspnoea Exertional | Respiratory, thoracic and mediastinal disorders |
|
| Epistaxis | Respiratory, thoracic and mediastinal disorders |
|
| Pleural Effusion | Respiratory, thoracic and mediastinal disorders |
|
| Pneumothorax | Respiratory, thoracic and mediastinal disorders |
|
| Pulmonary Embolism | Respiratory, thoracic and mediastinal disorders |
|
| Pulmonary Mass | Respiratory, thoracic and mediastinal disorders |
|
| Respiratory Failure | Respiratory, thoracic and mediastinal disorders |
|
| Hypoaesthesia Facial | Skin and subcutaneous tissue disorders |
|
| Skin Atrophy | Skin and subcutaneous tissue disorders |
|
| Skin Lesion | Skin and subcutaneous tissue disorders |
|
| Carotid Endarterectomy | Surgical and medical procedures |
|
| Coronary Revascularisation | Surgical and medical procedures |
|
| Hip Arthroplasty | Surgical and medical procedures |
|
| Hysterosalpingo-Oophorectomy | Surgical and medical procedures |
|
| Knee Arthroplasty | Surgical and medical procedures |
|
| Medical Device Implantation | Surgical and medical procedures |
|
| Renal Artery Stent Placement | Surgical and medical procedures |
|
| Therapeutic Embolisation | Surgical and medical procedures |
|
| Accelerated Hypertension | Vascular disorders |
|
| Aneurysm | Vascular disorders |
|
| Aortic Aneurysm | Vascular disorders |
|
| Arterial Stenosis | Vascular disorders |
|
| Arterial Stenosis Limb | Vascular disorders |
|
| Arteriovenous Fistula | Vascular disorders |
|
| Artery Dissection | Vascular disorders |
|
| Deep Vein Thrombosis | Vascular disorders |
|
| Femoral Arterial Stenosis | Vascular disorders |
|
| Femoral Artery Occlusion | Vascular disorders |
|
| Haemorrhage | Vascular disorders |
|
| Hypertension | Vascular disorders |
|
| Hypotension | Vascular disorders |
|
| Iliac Artery Stenosis | Vascular disorders |
|
| Intermittent Claudication | Vascular disorders |
|
| Ischaemia | Vascular disorders |
|
| Peripheral Artery Aneurysm | Vascular disorders |
|
| Peripheral Ischaemia | Vascular disorders |
|
| Peripheral Vascular Disorder | Vascular disorders |
|
| Poor Peripheral Circulation | Vascular disorders |
|
| Shock | Vascular disorders |
|
| Subclavian Steal Syndrome | Vascular disorders |
|
| Thrombosis | Vascular disorders |
|
| Vascular Pseudoaneurysm | Vascular disorders |
|
| Venous Insufficiency | Vascular disorders |
|
| Nausea | Gastrointestinal disorders |
|
| Chest Pain | General disorders |
|
| Fatigue | General disorders |
|
| Non-Cardiac Chest Pain | General disorders |
|
| Oedema | General disorders |
|
| Oedema Peripheral | General disorders |
|
| Back Pain | Musculoskeletal and connective tissue disorders |
|
| Pain In Extremity | Musculoskeletal and connective tissue disorders |
|
| Dizziness | Nervous system disorders |
|
| Dyspnoea | Respiratory, thoracic and mediastinal disorders |
|
| Hypertension | Vascular disorders |
|
Not provided
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |