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| ID | Type | Description | Link |
|---|---|---|---|
| ISRCTN01960869 | Other Identifier | a organization in UK |
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| Name | Class |
|---|---|
| Chinese PLA General Hospital | OTHER |
| Fudan University | OTHER |
| The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | OTHER |
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This is a multi-centre prospective randomized controlled trial to explore the influence of ischemia-reperfusion injuries elicited by pringle manoeuvre during radical excision on the prognosis of Hepatocellular Carcinoma (HCC) patients.
Until now there are two popular procedures during the radical excision of primary liver cancer in our country.One is to give a pringle manoeuvre to control the operative blood loss,the other is using a combination of CUSA and Tissue-link to control the bleeding while without liver ischemia.According to the recent experimental studies in rats,we know that the ischemia and reperfusion injury may contribute to the metastasis of the tumor.In order to test the actual contribution of ischemia on human,we conduct this prospective clinical trial to compare the two popular procedures' effect on the prognosis of liver cancer patients undergoing radical excision.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group A,non-pringle group | Experimental | Intervention of curative resection of HCC Without pringle manoeuvre in this arm |
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| pringle group(B) | Active Comparator | when the curative resection of HCC performed, the pringle manoeuvre will be routinely applied. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| curative resection without Pringle | Procedure | Radical excision of liver cancer without the procedure of pringle manoeuvre |
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| Measure | Description | Time Frame |
|---|---|---|
| Disease free survival | 1,3,5-year |
| Measure | Description | Time Frame |
|---|---|---|
| overall survival,morbidity,postoperative mortality;blood loss,Liver function test,etc | baseline~2 weeks, 5-year overall survival |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dong Jiahong, Ph D | Institue of hepatobiliary surgery,Chinese PLA General Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of hepatobiliary surgery,southwest hospital | Chongqing | Chongqing Municipality | 400038 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22862951 | Derived | Xiaobin F, Shuguo Z, Jian Z, Yudong Q, Lijian L, Kuansheng M, Xiaowu L, Feng X, Dong Y, Shuguang W, Ping B, Jiahong D. Effect of the pringle maneuver on tumor recurrence of hepatocellular carcinoma after curative resection (EPTRH): a randomized, prospective, controlled multicenter trial. BMC Cancer. 2012 Aug 3;12:340. doi: 10.1186/1471-2407-12-340. |
| Label | URL |
|---|---|
| Protocol | View source |
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| ID | Term |
|---|---|
| D006528 | Carcinoma, Hepatocellular |
| D007511 | Ischemia |
| D008113 | Liver Neoplasms |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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| First Affiliated Hospital, Sun Yat-Sen University |
| OTHER |
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| curative resection with Pringle manoeuvre | Procedure | curative resection liver cancer under pringle manoeuvre |
|
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| D009369 | Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D004066 | Digestive System Diseases |
| D008107 | Liver Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D008722 | Methods |