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| Name | Class |
|---|---|
| KAT Hospital of Athens | UNKNOWN |
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This is a prospective, open-label, randomized clinical trial where patients were administered prophylaxis for total hip or knee arthroplasty either with teicoplanin or with other antibiotics. The study is aiming to evaluate any differences between these two different strategies of antimicrobial prophylaxis in the occurrence of surgical site infections
This is a prospective, open-label, randomized clinical trial where patients were administered prophylaxis for total hip or knee arthroplasty either with a single dose of teicoplanin or with multiple doses of other antibiotics according to the habits of the attending physicians aiming to evaluate any differences between these two different strategies of antimicrobial prophylaxis in the occurrence of surgical site infections
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Surgical chemoprophylaxis of one dose of teicoplanin upon introduction of anesthesia for total hip or knee arthroplasty. |
|
| 2 | Active Comparator | Surgical chemoprophylaxis with multiple dose of other antimicrobials for up to six consecutive days for total hip or knee arthroplasty. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Teicoplanin | Drug | The selected dose was 10mg/kg and it was given intravenously by a catheter inserted under aseptic conditions in a forearm vein within 15 minutes; it was diluted in one 5% glucose solution of a 50 ml final volume |
| Measure | Description | Time Frame |
|---|---|---|
| To compare the efficacy of single dose teicoplanin compared with comparator agents in the prevention of surgical site infections after total hip or knee arthroplasty. | Two years |
| Measure | Description | Time Frame |
|---|---|---|
| To compare the efficacy of single dose teicoplanin compared with comparator agents in the separate prevention of superficial or deep surgical site infections after total hip or knee arthroplasty. | Two years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Helen Giamarellou, MD, PhD | 4th Department of Internal Medicine, University of Athens, Medical School, Greece | Study Chair |
| Amyntas Varvaroussis, MD | 3rd Department of Orthopedics, KAT Hospital, Maroussi, Greece | Principal Investigator |
| Panagiotis Papadelis, MD | 2nd Department of Orthopedics, KAT Hospital, Maroussi, Greece | Principal Investigator |
| Vassilios Nikolaidis, MD | 4th Department of Orthopedics, KAT Hospital, Maroussi, Greece | Principal Investigator |
| Antonios Papadopoulos, MD, PhD | 4th Department of Internal Medicine, University of Athens, Medical School, Greece | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 2nd Department of Orthopedics, KAT Hospital | Marousi | Athens | 14527 | Greece | ||
| 3rd Department of Orthopedics, KAT Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16424973 | Background | Soriano A, Popescu D, Garcia S, Bori G, Martinez JA, Balasso V, Marco F, Almela M, Mensa J. Usefulness of teicoplanin for preventing methicillin-resistant Staphylococcus aureus infections in orthopedic surgery. Eur J Clin Microbiol Infect Dis. 2006 Jan;25(1):35-8. doi: 10.1007/s10096-005-0073-z. | |
| 8144419 | Background |
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| ID | Term |
|---|---|
| D013530 | Surgical Wound Infection |
| ID | Term |
|---|---|
| D014946 | Wound Infection |
| D007239 | Infections |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D017334 | Teicoplanin |
| D006020 | Glycopeptides |
| D002939 | Ciprofloxacin |
| D002511 | Cephalosporins |
| ID | Term |
|---|---|
| D000077427 | Lipoglycopeptides |
| D006001 | Glycoconjugates |
| D002241 | Carbohydrates |
| D010455 | Peptides |
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|
| β-lactams or ciprofloxacin | Drug | Multiple doses for up to six consecutive days |
|
|
| Marousi |
| Athens |
| 14527 |
| Greece |
| 4th Department of Orthopedics, KAT Hospital | Marousi | Athens | 14527 | Greece |
| Wilson AP, Gruneberg RN, Neu H. Dosage recommendations for teicoplanin. J Antimicrob Chemother. 1993 Dec;32(6):792-6. doi: 10.1093/jac/32.6.792. No abstract available. |
| 9833102 | Background | Nehrer S, Thalhammer F, Schwameis E, Breyer S, Kotz R. Teicoplanin in the prevention of infection in total hip replacement. Arch Orthop Trauma Surg. 1998;118(1-2):32-6. doi: 10.1007/s004020050306. |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D000602 |
| Amino Acids, Peptides, and Proteins |
| D024841 | Fluoroquinolones |
| D042462 | 4-Quinolones |
| D015363 | Quinolones |
| D011804 | Quinolines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D047090 | beta-Lactams |
| D007769 | Lactams |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D013843 | Thiazines |
| D013457 | Sulfur Compounds |