The study objective is to compare outcomes in subjects with a diabetic foot ulcer after 16 weeks of consuming a medical food versus a calorically similar control drink.

Inclusion Criteria:

• non-pregnant
• diabetic
• neuropathic foot ulcer
• ABI> 0.7

Exclusion Criteria:

• uncontrolled DM
• collagen vascular disease or autoimmune disease
• wound infection; recent therapies with steroids
• growth factor or bioengineered tissue
• radiation therapy
• treatment with antibiotics within 1 week, Charcot's arthropathy of the foot
• active malignancy
• renal function impairment
• liver failure
• planned surgery
• myocardial infarction within 3 months
• malnutrition
• substance abuse
• taking conflicting oral nutritional supplements