The purpose of the study is to compare sensitivity and sensitization of visceral pain in the esophagus using different pain stimuli

Inclusion Criteria:

• Provision of written consent
• Clinically normal physical findings
• Sensitization potential

Exclusion Criteria:

• Clinically significant illness within 2 weeks prior to the first dose of investigational product
• History of clinically significant disease
• Use of prescribed medication during the 2 weeks before administration of the first dose of investigational product