Esophageal Hypersensitivity Study in Healthy Volunteers

A Phase I, Two Centre, Double-blind, Randomized, Cross-over Study to Evaluate AZD1386 in Single Doses of 30 mg and 95 mg Compared to Placebo in a Multimodal Experimental Pain Model on Esophageal Sensitivity and Development of Sensitization in Healthy Male Volunteers

The purpose of the study is to compare sensitivity and sensitization of visceral pain in the esophagus using different pain stimuli

Inclusion Criteria:

• Provision of written consent
• Clinically normal physical findings
• Sensitization potential

Exclusion Criteria:

• Clinically significant illness within 2 weeks prior to the first dose of investigational product
• History of clinically significant disease
• Use of prescribed medication during the 2 weeks before administration of the first dose of investigational product