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| Name | Class |
|---|---|
| Paragon Biomedical | INDUSTRY |
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Compare the efficacy of ABT-874 versus etanercept in subjects with moderate to severe plaque psoriasis
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A | Experimental |
| |
| B | Active Comparator |
| |
| C | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ABT-874 | Biological | SQ injection 200 mg Weeks 0 and 4; 100 mg Week 8 |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of subjects who achieve a PGA of 0 or 1 response relative to baseline at Week 12 | 12 Weeks | |
| Proportion of subjects who achieve a PASI 75 response relative to baseline at Week 12 | 12 Weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of subjects who achieve a PASI 100 response relative to baseline at Week 12 | 12 Weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Martin Kaul, MD | AbbVie | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Site Reference ID/Investigator# 9984 | Birmingham | Alabama | 35205 | United States | ||
| Site Reference ID/Investigator# 10605 |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21574984 | Derived | Strober BE, Crowley JJ, Yamauchi PS, Olds M, Williams DA. Efficacy and safety results from a phase III, randomized controlled trial comparing the safety and efficacy of briakinumab with etanercept and placebo in patients with moderate to severe chronic plaque psoriasis. Br J Dermatol. 2011 Sep;165(3):661-8. doi: 10.1111/j.1365-2133.2011.10419.x. Epub 2011 Jul 28. |
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| etanercept |
| Biological |
SQ injection 50 mg BIW |
|
| placebo | Drug | SQ placebo injections for ABT-874 and etanercept |
|
| Birmingham |
| Alabama |
| 35233 |
| United States |
| Site Reference ID/Investigator# 10001 | Scottsdale | Arizona | 85251 | United States |
| Site Reference ID/Investigator# 10502 | Little Rock | Arkansas | 72205 | United States |
| Site Reference ID/Investigator# 9985 | Bakersfield | California | 93309 | United States |
| Site Reference ID/Investigator# 10661 | Irvine | California | 92697 | United States |
| Site Reference ID/Investigator# 14701 | Los Angeles | California | 90045 | United States |
| Site Reference ID/Investigator# 9785 | San Diego | California | 92123 | United States |
| Site Reference ID/Investigator# 10662 | Santa Monica | California | 90404 | United States |
| Site Reference ID/Investigator# 10642 | Vallejo | California | 94589 | United States |
| Site Reference ID/Investigator# 10263 | New Haven | Connecticut | 06511 | United States |
| Site Reference ID/Investigator# 10503 | Jacksonville | Florida | 32204 | United States |
| Site Reference ID/Investigator# 10266 | Miami | Florida | 33144 | United States |
| Site Reference ID/Investigator# 9901 | Miami | Florida | 33173 | United States |
| Site Reference ID/Investigator# 10501 | West Palm Beach | Florida | 33407 | United States |
| Site Reference ID/Investigator# 15201 | Alpharetta | Georgia | 30022 | United States |
| Site Reference ID/Investigator# 10762 | Atlanta | Georgia | 30327 | United States |
| Site Reference ID/Investigator# 10262 | Newnan | Georgia | 30263 | United States |
| Site Reference ID/Investigator# 9789 | Snellville | Georgia | 30078 | United States |
| Site Reference ID/Investigator# 10666 | Maywood | Illinois | 60153 | United States |
| Site Reference ID/Investigator# 15142 | Plainfield | Indiana | 46168 | United States |
| Site Reference ID/Investigator# 10265 | Louisville | Kentucky | 40202 | United States |
| Site Reference ID/Investigator# 15750 | Owensboro | Kentucky | 42303 | United States |
| Site Reference ID/Investigator# 9790 | Owensboro | Kentucky | 42303 | United States |
| Site Reference ID/Investigator# 9788 | Fort Gratiot | Michigan | 48059 | United States |
| Site Reference ID/Investigator# 10604 | Grand Blanc | Michigan | 48439 | United States |
| Site Reference ID/Investigator# 10541 | Fridley | Minnesota | 55432 | United States |
| Site Reference ID/Investigator# 10641 | St Louis | Missouri | 63110 | United States |
| Site Reference ID/Investigator# 10606 | Omaha | Nebraska | 68131 | United States |
| Site Reference ID/Investigator# 10644 | Omaha | Nebraska | 68144 | United States |
| Site Reference ID/Investigator# 9786 | Berlin | New Jersey | 08009 | United States |
| Site Reference ID/Investigator# 10241 | New York | New York | 10016 | United States |
| Site Reference ID/Investigator# 9787 | Rochester | New York | 14623 | United States |
| Site Reference ID/Investigator# 9902 | Hickory | North Carolina | 28601 | United States |
| Site Reference ID/Investigator# 10581 | Wilmington | North Carolina | 28401 | United States |
| Site Reference ID/Investigator# 10504 | Dayton | Ohio | 45408 | United States |
| Site Reference ID/Investigator# 10643 | Knoxville | Tennessee | 37934 | United States |
| Site Reference ID/Investigator# 9981 | Dallas | Texas | 75230 | United States |
| Site Reference ID/Investigator# 10264 | San Antonio | Texas | 78229 | United States |
| Site Reference ID/Investigator# 9982 | Webster | Texas | 77598 | United States |
| Site Reference ID/Investigator# 10182 | Seattle | Washington | 98101 | United States |
| Site Reference ID/Investigator# 10321 | Milwaukee | Wisconsin | 53209 | United States |
| ID | Term |
|---|---|
| C544528 | briakinumab |
| D000068800 | Etanercept |
| ID | Term |
|---|---|
| D007141 | Immunoglobulin Fc Fragments |
| D007128 | Immunoglobulin Fragments |
| D010446 | Peptide Fragments |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D007127 | Immunoglobulin Constant Regions |
| D007136 | Immunoglobulins |
| D007162 | Immunoproteins |
| D001798 | Blood Proteins |
| D011506 | Proteins |
| D012712 | Serum Globulins |
| D005916 | Globulins |
| D018124 | Receptors, Tumor Necrosis Factor |
| D018121 | Receptors, Cytokine |
| D011971 | Receptors, Immunologic |
| D011956 | Receptors, Cell Surface |
| D008565 | Membrane Proteins |
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