Food Effect Study of a Single Dose of ZD4054 (Zibotentan)

A Randomised, Open-label, Single-centre, Crossover Study in Healthy Male Volunteers to Assess the Effect of Food on the Pharmacokinetics of a 10 mg Single Oral Dose of ZD4054 (Zibotentan)

The purpose of the study is to assess the effect of food on the pharmacokinetics of a 10 mg single oral dose of ZD4054 (Zibotentan)

Inclusion Criteria:

• BMI between 18 and 30 kg/m2
• Medical and surgical history and physical examination without any clinically significant findings
• Able to consume standard FDA specified high-fat breakfast.

Exclusion Criteria:

• Definite or suspected personal history or family history of hypersensitivity to drugs that are endothelin antagonists; ie, ambrisentan, artrasentan, sitaxsetan and bosentan
• Medical diagnosis of migraine with an attack during the 12 months prior to Screening
• Use of prescription medication within 2 weeks before dosing