The aim of this study is to evaluate the safety of the monoclonal antibody cocktail CL184 in combination with rabies vaccine compared with human rabies immune globulin (HRIG) in combination with rabies vaccine in healthy children and adolescents.

Inclusion Criteria:

• Subjects free of obvious health-problems or with stable conditions
• Male or female subject aged ≥5 to ≤18 years
• Subject is living, studying, or working close to the study referral site
• Parent or legal representative signed written informed consent; in addition for subjects ≥12 years: signed assent form

Exclusion Criteria:

• Prior history of rabies exposure or immunization (rabies vaccine and/or immune globulin)
• Acute infection or disease within the last 2 weeks
• History and/or family history of clinically significant immunodeficiency or auto-immune disease
• Any history of known or suspected anaphylaxis or hypersensitivity reaction
• Planned immunization with live vaccines during the next 3 months
• Chronic administration of immunosuppressants or other immune-modifying drugs within 6 months before the first dose of investigational medicinal product