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| ID | Type | Description | Link |
|---|---|---|---|
| 2U19AG056278-07A1 | U.S. NIH Grant/Contract | View source | |
| 3U19AG056278-06S1 | U.S. NIH Grant/Contract | View source | |
| P01AG021654 | U.S. NIH Grant/Contract | View source | |
| 1R56AG088624-01 | U.S. NIH Grant/Contract | View source | |
| R01AG088659 | U.S. NIH Grant/Contract | View source | |
| G42988 | Other Grant/Funding Number | American Federation for Aging Research |
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| Name | Class |
|---|---|
| National Institute on Aging (NIA) | NIH |
| American Federation for Aging Research | OTHER |
| Weill Medical College of Cornell University | OTHER |
| Boston University |
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We believe extreme longevity is due to specific genes which function to delay aging and prevent disease. The purpose of the research is to identify the genes/mutations associated with healthier aging; to understand the biological functions of these genes/mutations; and to develop therapies to replicate these preservative genetic activities in individuals who do not have the genetic profile for longevity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Probands | Ashkenazi Jews ages 95 and older | ||
| Offspring | Ashkenazi Jewish offspring of Ashkenazi Jewish parent(s) who lived to at least the age of 95 | ||
| Controls | Ashkenazi Jewish people with no family history of longevity |
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Inclusion Criteria:
Exclusion Criteria:
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Ashkenazi Jews:
Ages 95 and older, their offspring and control group with no family history of longevity.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tina Gao | Contact | 718-839-7176 | tina.gao@einsteinmed.edu |
| Name | Affiliation | Role |
|---|---|---|
| Nir Barzilai, MD | Albert Einstein College of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Private Homes | Recruiting | New York | New York | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34498278 | Result | DeVito LM, Barzilai N, Cuervo AM, Niedernhofer LJ, Milman S, Levine M, Promislow D, Ferrucci L, Kuchel GA, Mannick J, Justice J, Gonzales MM, Kirkland JL, Cohen P, Campisi J. Extending human healthspan and longevity: a symposium report. Ann N Y Acad Sci. 2022 Jan;1507(1):70-83. doi: 10.1111/nyas.14681. Epub 2021 Sep 8. | |
| 37657418 | Result | Moqri M, Herzog C, Poganik JR; Biomarkers of Aging Consortium; Justice J, Belsky DW, Higgins-Chen A, Moskalev A, Fuellen G, Cohen AA, Bautmans I, Widschwendter M, Ding J, Fleming A, Mannick J, Han JJ, Zhavoronkov A, Barzilai N, Kaeberlein M, Cummings S, Kennedy BK, Ferrucci L, Horvath S, Verdin E, Maier AB, Snyder MP, Sebastiano V, Gladyshev VN. Biomarkers of aging for the identification and evaluation of longevity interventions. Cell. 2023 Aug 31;186(18):3758-3775. doi: 10.1016/j.cell.2023.08.003. |
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| OTHER |
| Regeneron Pharmaceuticals | INDUSTRY |
| Harvard Medical School (HMS and HSDM) | OTHER |
| Stanford University | OTHER |
| Tufts Medical Center | OTHER |
| Columbia University | OTHER |
| University of Minnesota | OTHER |
| Rutgers Health | UNKNOWN |
| University of Rochester | OTHER |
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| Hebrew Home Riverdale | Recruiting | Riverdale | New York | 10471 | United States |
|
| 38355974 | Result | Moqri M, Herzog C, Poganik JR, Ying K, Justice JN, Belsky DW, Higgins-Chen AT, Chen BH, Cohen AA, Fuellen G, Hagg S, Marioni RE, Widschwendter M, Fortney K, Fedichev PO, Zhavoronkov A, Barzilai N, Lasky-Su J, Kiel DP, Kennedy BK, Cummings S, Slagboom PE, Verdin E, Maier AB, Sebastiano V, Snyder MP, Gladyshev VN, Horvath S, Ferrucci L. Validation of biomarkers of aging. Nat Med. 2024 Feb;30(2):360-372. doi: 10.1038/s41591-023-02784-9. Epub 2024 Feb 14. |
| 40615639 | Result | Bae H, Song Z, Ali A, Sasaki T, Tesi N, Lords H, Leshchyk A, Abe Y, Hirose N, Arai Y, Barzilai N, Weiss EF, Hulsman M, van der Lee S, van Schoor NM, Huisman M, Pijnenburg Y, van der Flier W, Reinders M, Holstege H, Milman S, Perls TT, Andersen SL, Sebastiani P. Increased genetic protection against Alzheimer's disease in centenarians. Geroscience. 2026 Apr;48(2):1815-1827. doi: 10.1007/s11357-025-01774-8. Epub 2025 Jul 4. |
| 40133344 | Result | Ali A, Zhang ZD, Gao T, Aleksic S, Gavathiotis E, Barzilai N, Milman S. Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity. Sci Rep. 2025 Mar 25;15(1):10199. doi: 10.1038/s41598-025-94094-y. |
| 39424787 | Result | Ying K, Castro JP, Shindyapina AV, Tyshkovskiy A, Moqri M, Goeminne LJE, Milman S, Zhang ZD, Barzilai N, Gladyshev VN. Depletion of loss-of-function germline mutations in centenarians reveals longevity genes. Nat Commun. 2024 Oct 19;15(1):9030. doi: 10.1038/s41467-024-52967-2. |
| 20926537 | Derived | Barzilai N, Gabriely I, Atzmon G, Suh Y, Rothenberg D, Bergman A. Genetic studies reveal the role of the endocrine and metabolic systems in aging. J Clin Endocrinol Metab. 2010 Oct;95(10):4493-500. doi: 10.1210/jc.2010-0859. |