An Interaction Study of Ketoconazole/Verapamil Versus AZD1305

A Phase I, Single-centre, Randomised, Open, Three-way Crossover Study to Evaluate the Effect of Ketoconazole and Verapamil, Respectively, on the Pharmacokinetics of AZD1305 After Repeated Oral Adm of Ketoconazole and Verapamil and Single Oral Dosing of AZD1305 to Young Healthy Male Volunteers

The purpose is to study whether ketoconazole or verapamil have an effect on how AZD1305 is handled by the body, i.e the absorption, distribution, metabolism and excretion, when administered in combination with AZD1305.

Inclusion Criteria:

• A body mass index (BMI=weight/height2) of 19 to 30 kg/m2

Exclusion Criteria:

• Potassium outside normal reference values
• ECG findings outside normal range