A Phase I Study in Healthy Volunteers to Assess Safety of BMS747158

A Single-Dose, Phase I, Dosimetry, Biodistribution, and Safety Trial of BMS 747158 in Healthy Subjects

The purpose of this clinical research study is to learn the safety and biodistribution of BMS747158 in normal, healthy volunteers.

Inclusion Criteria:

• age 18-40
• BMI 18-30 kg/m2
• No active or chronic illnesses
• If female: not pregnant, use of birth control or not of child-bearing potential

Exclusion Criteria:

• Significant active or chronic illness
• Any neurological disorder
• GI disease within 3 months
• Recent infection
• Major surgery within 4 weeks
• Donation of blood within 4 weeks
• Blood transfusion within 4 weeks
• Recent history drug/alcohol abuse
• Head trauma
• Significant screening ECG, EEG, lab tests, physical exam and vital signs abnormalities
• Prescription or OTC drugs within 2 weeks
• Exposure to any other investigational drug/device within 6