Effect of Genotyping for CYP450 Polymorphisms Versus Intense Clinical Monitoring on Antipsychotic Drug Treatment

A Three-armed Randomised Controled Trial on the Effect of Genotyping for CYP450 Polymorphisms and Intense Clinical Monitoring on Antipsychotic Drug Treatment.

The purpose of this study is to determine whether genotyping for CYP2D6 and 2C19 polymorphisms or intense clinical monitoring of treatment and adverse effects improves the antipsychotic treatment in patients with schizophrenia. This study is designed as a three-armed prospective randomized controlled clinical trial and includes 300 patients with schizophrenia. Patients are followed for a period of one year.

During the study period the following effect measures are registered:

• Time to discontinuation of all antipsychotic medications
• Number of changes in medication dose
• Number of changes in medication
• Compliance (patients´ adherence to medical treatment)
• Clinical symptoms
• Adverse effects

Inclusion Criteria:

• Diagnosed with schizophrenia
• Able to give written informed consent

Exclusion Criteria:

• Genotyped prior to inclusion