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The aim of the study is to investigate the effects of total intravenous anesthesia (TIVA; propofol, remifentanil) and balanced anesthesia (BAL; induction with propofol and fentanyl; maintenance of anesthesia with sevoflurane and nitrous oxide) on pulmonary function 30 minutes after emergence from the general anesthesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TIVA | Active Comparator | patients receiving total intravenous anesthesia (TIVA) |
|
| balanced | Active Comparator | patients receiving balanced anesthesia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| propofol | Drug | propofol 2mg/kg for induction of anesthesia; followed by propofol 6 mg/kg/hour |
| |
| Measure | Description | Time Frame |
|---|---|---|
| FEV1 forced expiratory volume; FVC forced vital capacity | preoperative, 30 minutes postoperative |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Arnulf Benzer, MD | TILAK Hospitals | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| TILAK Hospitals | Innsbruck | 6020 | Austria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 7793205 | Background | Gunnarsson L, Lindberg P, Tokics L, Thorstensson O, Thorne A. Lung function after open versus laparoscopic cholecystectomy. Acta Anaesthesiol Scand. 1995 Apr;39(3):302-6. doi: 10.1111/j.1399-6576.1995.tb04066.x. | |
| 16480344 | Background | Regli A, von Ungern-Sternberg BS, Reber A, Schneider MC. Impact of spinal anaesthesia on peri-operative lung volumes in obese and morbidly obese female patients. Anaesthesia. 2006 Mar;61(3):215-21. doi: 10.1111/j.1365-2044.2005.04441.x. |
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| ID | Term |
|---|---|
| D015742 | Propofol |
| D000077208 | Remifentanil |
| D005283 | Fentanyl |
| D000077149 | Sevoflurane |
| D009609 | Nitrous Oxide |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| propofol |
| Drug |
propofol 2mg |
|
| remifentanil | Drug | remifentanil 0,25mcg/kg/hour |
|
| fentanyl | Drug | fentanyl 100mcg |
|
| Sevoflurane/Nitrous Oxide | Drug | maintenance of anesthesia with sevoflurane and nitrous oxide |
|
| 12027846 | Background | Natalini G, Franceschetti ME, Pletti C, Recupero D, Lanza G, Bernardini A. Impact of laryngeal mask airway and tracheal tube on pulmonary function during the early postoperative period. Acta Anaesthesiol Scand. 2002 May;46(5):525-8. doi: 10.1034/j.1399-6576.2002.460509.x. |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D011422 | Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D009589 | Nitrogen Oxides |
| D005740 | Gases |
| D007287 | Inorganic Chemicals |
| D017672 | Nitrogen Compounds |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |