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Antigen expression levels in bone marrow from volunteering donors will be analyzed. The results of this analysis will be used to establish a clinical test to identify cancer patients who could qualify to receive an investigational treatment being developed by GlaxoSmithKline.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | donors |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bone marrow aspiration | Procedure | Collection of a 2 ml bone marrow sample from an aspirate carried out for medical purposes. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of copies of Wilms' Tumor 1 (WT1) antigen expression in bone marrow | Establishment of the range of WT1 transcript levels in a collection of bone marrow samples by real-time quantitative RT-PCR (Reverse Transcription Polymerase Chain Reaction). Due to the low numbers, they were expressed as [value x 10E-03]. Only the samples with gene expression >0 were presented. | At Day 0 |
| Number of copies of PRAME (Preferentially expressed in melanoma)antigen expression in bone marrow | Establishment of the range of PRAME transcript levels in a collection of bone marrow samples by real-time quantitative RT-PCR (Reverse Transcription Polymerase Chain Reaction). Due to the low numbers, they were expressed as [value x 10E-03]. Only the samples with gene expression >0 were presented. | At Day 0 |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| GSK Clinical Trials | GlaxoSmithKline | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| GSK Investigational Site | Ottignies | 1340 | Belgium |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
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