Sitagliptin Mechanism of Action Study in Patients With Type 2 Diabetes Mellitus (0431-059)

A Randomized, Placebo-Controlled Study to Evaluate the Safety, Efficacy and Mechanism of Action of MK0431/Sitagliptin in Patients With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control

A clinical study to determine the safety, efficacy and the way sitagliptin works in patients with Type 2 Diabetes Mellitus who have inadequate glycemic (blood sugar) control.

Inclusion Criteria:

• Participant has type 2 diabetes mellitus
• Males
• Females who are highly unlikely to become pregnant
• Participants poorly controlled without taking any, or taking one or two oral antidiabetic medications

Exclusion Criteria:

• Participant has a history of type 1 diabetes mellitus or history of ketoacidosis
• Participant required insulin therapy within the prior 8 weeks
• Participant is on or has been taking TZDs such as Actos® (pioglitazone) or Avandia® (rosiglitazone) within the prior 12 weeks of the screening visit