Durability of Nevirapine-Based Antiretroviral Regimen

Durability of Stavudine, Lamivudine and Nevirapine Among Advanced HIV-1 Infected Patients With/Without Prior Co-Administration of Rifampicin: A 144-Week Prospective Study

Although nevirapine is used as an alternative to efavirenz for initial regimen in developed countries, nevirapine has still been a key antiretroviral drug in many resource-limited countries including Thailand due to its accessibility and affordability. In addition, a component of stavudine and lamivudine is still widely used as a backbone in the antiretroviral regimen in this setting.To date, data on the durability of a regimen of stavudine, lamivudine and nevirapine are very limited, particularly from the resource-limited settings.

Inclusion Criteria:

• HIV-infected individuals ≥15 years of age
• CD4 cell count <350 cells/mm3
• Willing to participate and give consent form

Exclusion Criteria:

• previous antiretroviral therapy
• pregnancy
• receiving a medication that has drug-drug interactions with NVP or RFP
• aspartate aminotransferase (AST) and alanine aminotransferase (ALT) >5 times of upper limit of normal range