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This prospective study evaluate the immune status of patients admitted in ICU.CMV remains dormant in the body, but in people with immune deficiency, CMV could reactivate and cause life-threatening pneumonia.
Candidates will be screened with medical history and blood tests.Then, 2 groups of 20 patients (with or without CMV reactivation) matched for CMV status will be compared for their immune system against CMV.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Infection to CMV |
|
| 2 | Other | Group "control CMV" |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sampling of blood, phenotypic analysis sub-populations NK by cytometric of stream in multiple markings | Other | Sampling of blood |
|
| Measure | Description | Time Frame |
|---|---|---|
| Bring to light the quantitative and qualitative immunological modifications of the present cells NK before the arisen of an infection to CMV | 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Bring to light the quantitative and qualitative immunological modifications of cells NK in the consequences of an infectious shock | 24 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jean-Marie FOREL, MD | Assistance Publique des Hôpitaux de Marseille | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital de Sainte Marguerite- Service de Réanimation Médicale | Marseille | 13009 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23687088 | Derived | Matta J, Baratin M, Chiche L, Forel JM, Cognet C, Thomas G, Farnarier C, Piperoglou C, Papazian L, Chaussabel D, Ugolini S, Vely F, Vivier E. Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions. Blood. 2013 Jul 18;122(3):394-404. doi: 10.1182/blood-2013-01-481705. Epub 2013 May 17. | |
| 23236375 |
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| Sampling of blood, phenotypic analysis sub-populations NK by cytometric of stream in multiple markings | Other | Sampling of blood |
|
| Forel JM, Chiche L, Thomas G, Mancini J, Farnarier C, Cognet C, Guervilly C, Daumas A, Vely F, Xeridat F, Vivier E, Papazian L. Phenotype and functions of natural killer cells in critically-ill septic patients. PLoS One. 2012;7(12):e50446. doi: 10.1371/journal.pone.0050446. Epub 2012 Dec 6. |
| ID | Term |
|---|---|
| D003586 | Cytomegalovirus Infections |
| ID | Term |
|---|---|
| D006566 | Herpesviridae Infections |
| D004266 | DNA Virus Infections |
| D014777 | Virus Diseases |
| D007239 | Infections |
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