To test the effect of Nexium and probiotics on insulin secretion and cardiovascular risk factors on type 2 diabetic patients.

Study Hypothesis:

1. Nexium causes an increased gastrin secretion that increases the insulin secretion and thereby a reduction of HbA1c
2. Probiotics changes the gut flora and bloodpressure
3. Probiotics causes a change in inflammation and thrombosis.

Inclusion Criteria:

• Type 2 diabetes (WHO criteria) treated with metformin and/or sulfonylureas or diet
• Males and females between 40 and 70 years
• HbA1c between 6,0-10,0
• Diabetes duration > 1 year

Exclusion Criteria:

• Kidney disease (s-creatinine above the upper limit of normal range).
• Liver disease (ALAT increase > 3 times the upper limit of the normal range of ALAT).
• Macroalbuminuria (urinary albumin excretion of > 300 mg/day).
• Heart failure(NYHA class lll or lV)
• Severe neuropathy (symptoms + vibration perception threshold > 50 measured by biothesiometer.)
• Neutropenia (neutrophil count<2.0x10/l) or anemia (hemoglobin<8mM for men or <7mM for women.
• Alcohol abuse
• Drug abuse
• Severe organic or metabolic diseases including cancer
• C-peptide< 0,3 pmol/l
• Medicine interaction
• Treatment with insulin
• PPI or other medications for ulcus diseases
• Treatment with warfarin or other coumarin derivations
• Pregnant or breastfeeding women
• Allergy to medication used in the study
• Participants may not participate in another clinical intervention trial