Radiotherapy Planning Based on Positron Emission Tomography With Fluoro-deoxyglucose For Advanced NSCLC

Optimisation of Radiotherapy-Planning in Patients With Inoperable Locally Advanced Non-Small-Cell Lung Cancer by FDG-PET

Simultaneous radio-chemotherapy in advanced non-small cell lung cancer. The study focusses on a randomised comparison of conventional radiotherapy planning with irradiation of macroscopic tumor and lymph nodes together with prophylactic target volumes vs. irradiation only of FDG-positive lesions.

Primary endpoint is the local disease control in the chest.

Simultaneous radio-chemotherapy in advanced non-small cell lung cancer. The study focusses on a randomised comparison of conventional radiotherapy planning with irradiation of macroscopic tumor and lymph nodes together with prophylactic target volumes vs. irradiation only of FDG-positive lesions.

Primary endpoint is the local disease control in the chest

Inclusion Criteria:

• histologically proved NSCLC
• UICC-stage I-III, no resection planned
• complete staging < 6 wks before treatment including cranial CT
• ECOG <3, Karnofsky-Index >60%
• age > 18 <
• FEV1 > 1,0 l or >35%
• RT-planning according to protocol feasible
• chemotherapy feasible
• written informed consent

Exclusion Criteria:

• neuroendocrine tumors, plain broncho-alveolar-cell ca.
• distant metastases, supraclavicular lymph node metastases
• malignant pleural effusion
• resection of actual tumor performed
• inclusion in other study protocol
• chemotherapy due to actual tumor before FDG-PET
• induction-chemotherapy
• acute vena cava superior syndrome
• second malignancy other than basalioma
• pregnancy, lactation
• heart insufficiency NYHA III/IV
• pneumoconiosis with active inflammatory changes of mediastinal lymph nodes
• acute broncho-pulmonary infection at time of PET-examination