Repeated High-dose Inhaled Corticosteroids for Asthma

Repeated High-dose Inhaled Corticosteroids for Asthma

The purpose of this study is to to compare the effects of high-dose Inhaled Corticosteroids (ICS) vs. placebo in adults with chronic stable asthma.

Inclusion criteria:

• Physician diagnosis of asthma.

• Age ≥18 years and ≤50 years

• Evidence of airflow obstruction as measured by spirometry and flow-volume loop per American Thoracic Society guidelines.

• Treatment for asthma with:

  • daily inhaled corticosteroids and long-acting beta2-agonists, AND
  • as-needed use of a short-acting beta2-agonist

Exclusion criteria:

• History of >10 pack-year tobacco use
• Other pulmonary or cardiac diagnosis that is actively being treated
• History of adverse events or allergy to fluticasone
• Systemic corticosteroid therapy within 7 days of study visit
• Inability to obtain written informed consent