Survival Study in Patients Undergoing On-line Hemodiafiltration

A Randomized Study to Evaluate Survival in Patients Undergoing Hemodialysis or On-line Hemodiafiltration

Patients on hemodialysis will be randomly assigned (1:1) to continue on conventional hemodialysis or on-line hemodiafiltration, both three times per week. A 3 year follow-up and a sample size of around 750 will be necessary to detect a 35% reduction in mortality.

Inclusion Criteria:

• Age 18 and older
• Currently undergoing hemodialysis
• Clinical stability
• Stable vascular access

Exclusion Criteria:

• Chronic inflammatory diseases
• Liver cirrhosis
• Malignancies
• Chronic immunosuppressant or antiinflammatory use
• Dialysis through temporary catheter or single puncture