This study will evaluate the treatment effect of three doses of the I-vation TA implant (MK0140) in diabetic patients with clinically significant macular edema.

Inclusion Criteria:

• Patient has clinically significant macular edema as a result of their diabetes (Type I or Type 2)
• Patient has in the study eye, 20/40 - 20/160 vision
• Patient has Type 1 or Type 2 diabetes
• Patient agrees to remain abstinent or use (or have their partner use) 2 acceptable methods of birth control

Exclusion Criteria:

• Patient has had any active ocular infection in either eye
• Patient has intraocular pressure > 22 mmHg or a diagnosis of glaucoma
• Patient has cystoid macular edema in the study eye
• Patient has a history of elevated IOP in response to ocular steroid therapy in either eye
• Patient has had intraocular surgery in the study eye within 6 months prior to Visit 1
• Patient has an HbAIc value > 10% at Visit 1
• Patient has within the last 4 months initiated intensive insulin treatment or plan to do so in the next 4 months
• Patient has a history of cancer within 5 years prior to signing informed consent
• Patient has clinically-relevant chronic renal failure
• Patient has high blood pressure
• Patient has coronary heart disease
• Patient has known allergies to steroids