Force Enhancement of Musculus Quadriceps Femoris During a... | NCT00690547

Studies
Force Enhancement of Musculus Quadriceps Femoris During and After Excentric Muscle Activity in Vivo

NCT00690547

Sponsor

German Research Foundation

Status

Unknown status

Last Update Posted

Nov 30, 2009Estimated

Enrollment

60Estimated

Phase

Not provided

Conditions

Muscle Quadriceps Femoris
Healthy

Interventions

muscle activation

Countries

Germany

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Nov 2009

Overall Recruitment Status or Expanded Access Status

Unknown status

Last Known Status

Active, not recruiting

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Oct 2008

Primary Completion Date

Oct 2010Estimated

Completion Date

Oct 2010Estimated

First Submitted Date

May 30, 2008

First Submission Date that Met QC Criteria

Jun 3, 2008

First Posted Date

Jun 4, 2008Estimated

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Nov 27, 2009

Last Update Posted Date

Nov 30, 2009Estimated

Oversight Module

Has Data Monitoring Committee (DMC)

Is FDA Regulated Drug

Not provided

Is FDA Regulated Device

Not provided

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

Not provided

FDAAA801 Violation

Not provided

Description Module

Brief Summary

Force enhancement (FE) describes the phenomenon of strength potentialization of a muscle cell or the complete muscle during and after active extension compared to the strength of an isometric contraction with same muscle length. The underlying physiological mechanism of this phenomenon is not completely known today. In vitro trials indicate that the interaction of an active and a passive component on the cellular level are responsible for the higher strength measurements. So far FE could be shown in vitro and in vivo on muscle fibers and small human muscles. Further research is needed for verification of the existence of FE in voluntary motor activity in everyday life. In order to approach this objective the investigators will scrutinize the functionality of the deliberately activated musculus (m) quadriceps femoris during and after active extension on the basis of in vivo studies.

Detailed Description

The research proposal is resubmitted with no amendments made regarding content.

Design Module

Study Type

Observational

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Not provided

Target Follow-Up Duration

Not provided

Phases

Not provided

Interventional Study Design

Allocation

Not provided

Intervention Model

Biospecimen

No data available

No data is available for this block.

Enrollment

60Estimated

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Test Group			Other: muscle activation

Interventions

Name	Type	Description	Arm Group Labels	Other Names
muscle activation	Other	activation of the muscle quadriceps femoris	Test Group

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Identification of a potential Force enhancement by complex muscle activity with a high relevance for everyday life, for example more agile leg stretching (knee bend).		12 months

Secondary Outcomes

Measure	Description	Time Frame
Evidence of existence of the force enhancement by deliberately activated, great human muscle by sub-maximal activation		12 months
Correlation between typ of muscle fiber and force enhancement in vivo		12 months

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Males without previous muscular or neurophysiological diseases
Age between 20 and 40 years

Exclusion Criteria:

Previous muscular or neurophysiological diseases

Accepts Healthy Volunteers

Yes

Sex

Male

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

20 Years

Maximum Age

40 Years

Standard Ages

Adult

Study Population

males without previous muscular or neurophysiological diseases at an age between 20 and 40 years

Sampling Method

Non-Probability Sample

Contacts/Locations Module

Central Contacts

Not provided

Overall Officials

Name	Affiliation	Role
Ansgar Schmirtz, Prof. Dr.	Technical University of Munich, Department of Biomechanics in Sports	Principal Investigator

Locations

Facility	Status	City	State	ZIP	Country	Contacts
Technical University of Munich, Department of Biomechanics in Sports		Munich		80809	Germany