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The purpose of this study is to assess the effect of AZD6370 on blood sugar and to study safety and tolerability in patients with type 2 diabetes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Part A, arm 1 | Experimental | 1) 8 pats: AZD6370 increasing oral single doses a+b+c+placebo together with food |
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| Part A, arm 2 | Experimental | 1) 8 pats: AZD6370 increasing oral single doses a+b+c+placebo without food |
|
| Part B, arm1, 2, and 3 | Experimental |
|
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| Part B, arm 4 | Experimental | 4) Placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AZD6370 | Drug | Oral single doses a+b+c, o.d., suspension |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Pharmacodynamic variables | Blood samples taken repeatedly during 24 hours on study day sessions |
| Measure | Description | Time Frame |
|---|---|---|
| Safety variables | Blood samples taken repeatedly during 24 hours on study day sessions | |
| Pharmacokinetic variables | Blood samples taken repeatedly during 24 hours on study day sessions |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Klas Malmberg, MD, PhD, Prof. | AstraZeneca R&D Mƶlndal, SE-431 83 Mƶlndal, Sweden | Study Director |
| Wolfgang Kühn, MD | Quintiles AB, Phase I Services, Strandbodgatan 1, SE-753 23 Uppsala, Sweden | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Site | Linkƶping | Sweden | ||||
| Research Site |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23010558 | Derived | Ericsson H, Sjoberg F, Heijer M, Dorani H, Johansson P, Wollbratt M, Norjavaara E. The glucokinase activator AZD6370 decreases fasting and postprandial glucose in type 2 diabetes mellitus patients with effects influenced by dosing regimen and food. Diabetes Res Clin Pract. 2012 Dec;98(3):436-44. doi: 10.1016/j.diabres.2012.09.025. Epub 2012 Sep 23. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| C576406 | 3-(2-hydroxy-1-methylethoxy)-N-(1-methyl-1H-pyrazol-3-yl)-5-(4-(methylsulfonyl)phenoxy)benzamide |
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| AZD6370 |
| Drug |
Oral single dose, o.d., b.i.d. and q.i.d., suspension |
|
| Placebo | Drug | Placebo |
|
| LuleƄ |
| Sweden |
| Research Site | Uppsala | Sweden |
| D004700 | Endocrine System Diseases |