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To determine whether or not spironolactone can prevent or delay the occurrence of atrial fibrillation.
To determine whether or not adding spironolactone can prevent or delay the occurrence of paroxysmal atrial fibrillation in patients who have received propafenone treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| III | Placebo Comparator | Placebo |
|
| Experimental | Experimental | Drug intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Spironolactone | Drug | 25 mg po qd 25 mg po bid |
|
| Measure | Description | Time Frame |
|---|---|---|
| time to a first electrocardiographically confirmed AF | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| 1. Response rate: Improvement of any symptom scores and/or SF36 scores more than 50 % (compared with re-randomization scores) 2. Difference of mean episodes of documented AF between the spironolactone and placebo groups. | 3 months |
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Inclusion criteria:
Exclusion criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tsu-Juey Wu, M.D. | Contact | 886-4-23592525 | 4043 | tjwu@vghtc.vghtc.gov.tw |
| Name | Affiliation | Role |
|---|---|---|
| Tsu-Juey Wu, M.D. | TCVGH | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Taichung General Hospital | Recruiting | Taichung | 40705 | Taiwan |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D013148 | Spironolactone |
| ID | Term |
|---|---|
| D007783 | Lactones |
| D009930 | Organic Chemicals |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 |
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| Placebo | Drug | Spironolactone 25 mg po qd |
|
|
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |