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| Name | Class |
|---|---|
| Special Trustees for St Thomas' and Guy's Hospitals | UNKNOWN |
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The purpose of this study is to determine whether adults with disoociative (psychogenic non-epileptic) seizures receiving cognitive behavioural therapy (CBT) show a greater reduction in seizures and health service use and greater improvement in employment status and overall psychosocial functioning than patients who receive standard care.
Preliminary results from a pilot study demonstrated that cognitive behavioural therapy (CBT) is associated with a significant benefit for patients with dissociative seizures. The current study aims to extend these findings by conducting a randomised controlled trial comparing CBT with standard outpatient medical care. Standard outpatient care has been chosen as the comparison treatment as it most closely resembles what is currently offered to this group of patients by the National Health Service. The primary outcome measure will be seizure frequency. Secondary outcome measures will be work and social adjustment and health service use.
Our hypothesis is that CBT will be superior to standard outpatient care for patients with dissociative seizures as determined by the above measures.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Cognitive behavioural Therapy |
|
| 2 | Active Comparator | Standard Care |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CBT | Behavioral | CBT, up to 12 sessions. |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| seizure frequency | previous month |
| Measure | Description | Time Frame |
|---|---|---|
| seizure freedom | 3 months | |
| Work & Social Adjustment scale (Marks, 1986) | Pre-treatment, end of treatment and six-months follow-up | |
| Employment Status |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Laura Goldstein | Institute of Psychiatry | Study Director |
| John Mellers | Maudsley Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maudsley Hospital | London | SE5 8AF | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15209224 | Background | Goldstein LH, Deale AC, Mitchell-O'Malley SJ, Toone BK, Mellers JD. An evaluation of cognitive behavioral therapy as a treatment for dissociative seizures: a pilot study. Cogn Behav Neurol. 2004 Mar;17(1):41-9. doi: 10.1097/00146965-200403000-00005. |
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| ID | Term |
|---|---|
| D000091323 | Psychogenic Nonepileptic Seizures |
| D012640 | Seizures |
| D004213 | Dissociative Disorders |
| D004827 | Epilepsy |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D015928 | Cognitive Behavioral Therapy |
| D059039 | Standard of Care |
| ID | Term |
|---|---|
| D001521 | Behavior Therapy |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
| D019984 | Quality Indicators, Health Care |
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| Standard Care | Behavioral | Routine review by neuropsychiatrist in outpatient clinic |
|
|
| Pre-treatment, end of treatment and six-months follow-up |
| Health Service Use | Pre-treatment, end of treatment and six-months follow-up |
| Hospital Anxiety and Depression Scale (Zigmond & Snaith, 1983) | Pre-treatment, end of treatment and six-months follow-up |
| D001523 | Mental Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D011787 | Quality of Health Care |
| D006298 | Health Services Administration |
| D017530 | Health Care Quality, Access, and Evaluation |