Reduced Intensity Transplant in Medically Refractory Systemic Lupus Erythematosus (SLE) and Systemic Sclerosis (SSc)

Reduced Intensity Conditioning And Allogeneic Stem Cell Transplantation in Patients With Medically Refractory Systemic Lupus Erythematosus and Medically Refractory Systemic Sclerosis (SSc)

The purpose of this study is to determine if a reduced intensity (RI) (non-myeloablative) chemoimmunotherapy followed by Allogeneic Stem Cell Transplantation AlloSCT (matched family donors and matched unrelated cord blood donors) will be well tolerated.

This is to test whether a reduced intensity will result in a high degree of mixed or complete donor chimerism and stabilization of autoimmune disease in a select group of patients with medically refractory SLE or SSc.

Inclusion Criteria:

• Diffuse Systemic Sclerosis and variants as per ACR criteria
• Medically refractory disease
• Adequate Organ Function - Pulmonary function
• Renal function, Cardiac function defined as:
• SGOT (AST) or SGPT (ALT) <5 x upper limit of normal
• Diagnosis of SLE - Medically refractory disease

Exclusion Criteria:

• Karnofsky/Lansky <60%