The purpose of this study is to evaluate the effect of choline fenofibrate on the regression of macular edema in eyes of subjects with type 2 diabetes mellitus (T2DM) presenting with diabetic macular edema (DME)

Inclusion Criteria

• With DME in at least one eye of the subject and this eye presenting with macula thickness ≥ 300 µm on OCT examination at baseline in at least one of the 5 following zones: center zone, or superior inner zone, or nasal inner zone, or inferior inner zone, or temporal inner zone, confirmed after central reading of the OCT;
• When laser treatment can be safely postponed by up to at least 3 months;
• With established T2DM and HbA1c < 10%;
• With systolic blood pressure (SBP) or diastolic blood pressure (DBP) < 160/90 mmHg;
• With documented elevated triglyceride levels (TG >=150 mg/dL [1.70 mmol/L]) at the screening visit or in the previous 3 months.

Exclusion Criteria

• Previous laser photocoagulation;
• Eye retinal thickening results from epiretinal membranes or vitreomacular traction; glaucoma;
• Poor visual acuity: visual acuity of 20/800