Significance of the High-risk Hpv Viral Load

Significance of the High-risk Hpv Viral Load

The aim of this study is to evaluate the significance of an elevated high-risk HPV (HR-HPV) viral load.

We will particularly evaluate if the HR-HPV viral load:

• Is correlated to the transcription of the genes of the oncoproteins E6 and E7
• Is predictive of the integration of the virus in infected cells
• Is predictive of the presence of HPV in patients' blood
• Influences the local and systemic immunologic response

Inclusion Criteria:

• The women consulting for the therapeutic care (by hysterectomy or conization) of a LIEHG or a cervical cancer (carcinoma epidermoid or adenocarcinoma) confirmed by the anatomopathologique analysis of a preoperative cervical biopsy.
• The women having a normal cervix consulting for the surgical care by hysterectomy of a good-hearted pathology of the womb. The normality of the cervix will be confirmed by the anatomopathologique analysis of the detail of hysterectomy
• The patients participating in this study will have to be of more than 18 years old. All the subjects will be profitable of a regime of Social Security.

Exclusion Criteria:

• The patients having a LIEBG
• The patients incapable to receive the information enlightened on the progress and the objectives of the study
• The patients not having signed enlightened assent