Dose Escalation Study With Zactima and Chemotherapy in Metastatic Pancreas Carcinoma

Dose Escalation Study of the Combination of ZD6474, Gemcitabine and Capecitabine in Locally Advanced Unresectable or Metastatic Pancreatic Adenocarcinoma

The purpose of this study is to define th Maximum Tolerated Dose (MTD) and the recommended dose (RD) of ZD6474 in combination with a fixed standard dose of gemcitabine and capecitabine

Inclusion Criteria:

• Confirmed diagnosis of locally advanced unresectable or metastatic pancreatic adenocarcinoma
• ECOG performance status <1
• Measurable disease

Exclusion Criteria:

• Severe or uncontrolled systemic disease
• Clinically significant cardiac event such as myocardial infarction
• Any concomitant medication that may cause OTc prolongation, include Torsades de Pointes