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To study the effect of sibutramine treatment on weight reduction and blood pressure improvement in three groups with antihypertensive therapy whose blood pressure was not adequately controlled with antihypertensive combination treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | verapamil/trandolapril |
|
| 2 | Active Comparator | metoprolol/HCT |
|
| 3 | Active Comparator | felodipine/ramipril |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| sibutramine | Drug | 8-wks, sibutramine, 10 mg, capsules, once daily |
|
| Measure | Description | Time Frame |
|---|---|---|
| Systolic Blood Pressure | Duration of Study | |
| Diastolic Blood Pressure | Duration of Study |
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Inclusion Criteria:
Exclusion Criteria:
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| sibutramine | Drug | 8-wks, sibutramine, 15 mg, capsules, once daily |
|
|
| verapamil/trandolapril | Drug | 2 wk Run-in phase, antihypertensive therapy only |
|
| metoprolol/HCT | Drug | 2 wk Run-in phase, antihypertensive therapy only |
|
| felodipine/ramipril | Drug | 2 wk Run-in phase, antihypertensive therapy only |
|
| ID | Term |
|---|---|
| D009765 | Obesity |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| C058254 | sibutramine |
| D014700 | Verapamil |
| C052035 | trandolapril |
| D015736 | Felodipine |
| D017257 | Ramipril |
| ID | Term |
|---|---|
| D010627 | Phenethylamines |
| D005021 | Ethylamines |
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D004095 | Dihydropyridines |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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