Topical CP-690,550 For Chronic Plaque Psoriasis

PHASE 2A RANDOMIZED, DOUBLE-BLIND, VEHICLE-CONTROLLED, INTRA-INDIVIDUAL COMPARISON TRIAL ASSESSING SAFETY, TOLERATION, PHARMACOKINETICS AND PILOT EFFICACY OF 4 WEEKS TREATMENT WITH TOPICAL CP-690,550 IN CHRONIC PLAQUE PSORIASIS

Study will test effectiveness of an experimental drug applied once or twice daily to two psoriasis plaques. Requires 1 clinic visit each week for 5 weeks.

Inclusion Criteria:

• Having chronic plaque psoriasis for at least 6 months
• Able to withdraw all prior psoriasis treatments
• Must agree to avoid prolonged exposure to the sun and avoid use of tanning booths or other ultraviolet light sources during the study

Exclusion Criteria:

• Evidence of active, latent, or inadequately treated infection with Mycobacterium tuberculosis
• Pregnant or lactating women
• Unwilling to use appropriate contraceptive methods