Study Evaluating Safety and Efficacy of Bazedoxifene/Conjugated Estrogens Combinations in Postmenopausal Women

A Double-Blind, Randomized, Placebo- and Active-Controlled Safety and Efficacy Study of Bazedoxifene/Conjugated Estrogens Combinations in Postmenopausal Women

The purpose of this study is to determine whether bazedoxifene/conjugated estrogens combinations are effective for the prevention of endometrial hyperplasia and for the prevention of osteoporosis in postmenopausal women.

Inclusion Criteria:

• Generally healthy, postmenopausal women aged 40 - 75 years inclusive
• Intact uterus
• Last natural menstrual cycle (without exogenous hormone therapy) completed at least 12 consecutive months before screening

Exclusion Criteria:

• A history or active presence of thrombophlebitis, thrombosis or thromboembolic disorders
• A history or active presence of cerebrovascular accident, stroke, or transient ischemic attack
• A history or active presence of malignancy, or treatment for malignancy, within the previous 10 years

Additional criteria applies.