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Hurricane- terminated study due to skin bank being destroyed
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To determine if Amnion, used on partial thickness burn injuries would provide an improvement in rate of healing, pain control and scarring as compared to standard medical treatments.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Amnion with processing procedures involving the use of trypsin-Edetic Acid(EDTA) |
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| 2 | Experimental | Amnion with processing procedures involving the use of Dispase II |
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| 3 | Active Comparator | Prepared Antibiotic ointment Polysporin, Bacitracin and Mycostatin |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Amnion | Biological | Application of Amnion with processing procedures involving the use of trypsin-EDTA |
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| Measure | Description | Time Frame |
|---|---|---|
| Length of time to 95% healing of treated burn wounds | Assessment daily until 95 % healed |
| Measure | Description | Time Frame |
|---|---|---|
| Length of hospital stay | Measured at hospital discharge | |
| Incidence of infection | Measure daily until complete wound healing | |
| Amount of daily pain until wound is healed with different treatments. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| David N Herndon, MD | University of Texas | Principal Investigator |
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| ID | Term |
|---|---|
| D002056 | Burns |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| C030910 | cancer procoagulant |
| C069612 | bacitracin, polymyxin B drug combination |
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| Amnion | Biological | Application of Amnion with processing procedures involving the use of Dispase II |
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| Polysporin/Bacitracin/Mycostatin | Drug | Application of Prepared antibiotic ointment: Polysporin, Bacitracin and Mycostatin combined |
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| Daily until wound is completely healed. |
| Amount of scaring with different treatments | From injury to 2 years post burn |