The aim of the study is to investigate if P6 acupuncture made after induction of general anaesthesia might be effective for the prevention of PONV as ondansetron and if the acupuncture-ondansetron combination could enhance single therapy efficacy in patients undergoing laparoscopic cholecystectomy.

Inclusion Criteria:

• Patients ASA I-II scheduled for elective laparoscopic cholecystectomy.

Exclusion Criteria:

• Patient's refusal
• Patients with history of carpal tunnel syndrome or eczema at P6 point
• Pregnant patients
• Female patients in a phase of the menstrual cycle other than premenstrual, nausea and vomiting within 24 hours before anaesthesia
• Known allergy to anti-inflammatory drugs, opioids and ondansetron.
• Patients with a pre-existing chronic pain disorder or with a gastrointestinal disease.