Pharmacokinetics of Daunomycin in Children
Pharmacokinetics of Daunomycin in Children
This laboratory study is looking at the pharmacokinetics of daunorubicin in young patients with cancer. Collecting and storing samples of blood from patients with cancer to study in the laboratory may help doctors learn more about how patients respond to treatment with certain chemotherapy drugs.
OBJECTIVES:
Primary
Secondary
OUTLINE: This is a multicenter study.
Patients undergo blood collection prior to, periodically during, and after treatment with daunorubicin hydrochloride for pharmacokinetic analysis.
Patients also undergo body composition testing within 7 days before or after the administration of daunorubicin hydrochloride using dual-energy x-ray absorptiometry.
PROJECTED ACCRUAL: A total of 100 patients will be accrued for this study.
DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
Indianapolis, Indiana 46202-5289, United States
Lexington, Kentucky 40536-0093, United States
Boston, Massachusetts 02115, United States
Ann Arbor, Michigan 48109-0286, United States
Grosse Pointe Woods, Michigan 48236, United States
Minneapolis, Minnesota 55404, United States
Columbia, Missouri 65203, United States
St Louis, Missouri 63110, United States
New York, New York 10032, United States
Portland, Oregon 97239-3098, United States
Charleston, South Carolina 29425, United States
Dallas, Texas 75390, United States
Spokane, Washington 99220-2555, United States
Milwaukee, Wisconsin 53226, United States