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| ID | Type | Description | Link |
|---|---|---|---|
| BJHLG-20061B0501900035 |
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| Name | Class |
|---|---|
| Peking University | OTHER |
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The purpose of this study is to determine whether Extract of Ginkgo Biloba is effective in the treatment on Tardive dyskinesia
Tardive dyskinesia(TD) is a common complication of conventional antipsychotic treatment in subjects with schizophrenia. There is no established treatment for TD patients.This disorder remains a significant clinical problem for both patients and physicians for the foreseeable future.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A | Experimental | Active treatment with EGb-761 capsules (80mg each capsule), 3 capsules each day for 12 weeks |
|
| B | Placebo Comparator | Matching placebo treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Extract of Ginkgo Biloba (EGb-761 capsules) | Drug | EGb-761 240mg/d, 1 capsule(80mg) tid,po,12 weeks; Each capsule contains 19.6mg flavonol glycosides and 4.8mg terpene lactones. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in the scores of Abnormal Involuntary Movement Scale (AIMS) | Baseline, 6th and 12th week |
| Measure | Description | Time Frame |
|---|---|---|
| Change in PANSS | Baseline, 6th and 12th week | |
| Change in Simpson-Angus Rating Scales for EPS | Baseline, 6th and 12th | |
| Change in cognitive function |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yunlong Tan, Phd | Beijing HuiLongGuan Hospital | Principal Investigator |
| Dongfeng Zhou, Professor | Institute of mental health, Peking University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Hui-Long-Guan Hospital | Beijing | 100096 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20868638 | Derived | Zhang WF, Tan YL, Zhang XY, Chan RC, Wu HR, Zhou DF. Extract of Ginkgo biloba treatment for tardive dyskinesia in schizophrenia: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2011 May;72(5):615-21. doi: 10.4088/JCP.09m05125yel. Epub 2010 Sep 21. |
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| ID | Term |
|---|---|
| D000071057 | Tardive Dyskinesia |
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D004409 | Dyskinesia, Drug-Induced |
| D020820 | Dyskinesias |
| D009069 | Movement Disorders |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| C063170 | Ginkgo biloba extract |
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|
| Placebo | Drug | Wheat flour placebo capsule,1 capsule tid, po,12 weeks |
|
| Baseline and 12th week |
| Change in Udvalg for Kliniske Undersøgelser (UKU) Side Effect Rating Scale | Baseline, 6th and 12th week |
| D009422 | Nervous System Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |