Effect of Dietary Polyphenols on Insulin Sensitivity

Effect of Dietary Polyphenols on Insulin Sensitivity

A large and growing segment of the population is prediabetic. Dietary interventions that improve insulin sensitivity may be important in preventing the progression to full-blown diabetes in these individuals. Foods and dietary compounds that increase insulin sensitivity are likely to help maintain a healthier body composition. This pilot study will provide data to evaluate the role of dietary plant polyphenols in improving insulin sensitivity.

How does the amount consumed of cocoa and tea polyphenols (flavon-3-ol monomers and oligomers) affect insulin sensitivity in insulin resistant individuals?

Inclusion Criteria:

• Individuals who are insulin resistant based on routine clinical measurements (Stern et al., 2005).

Exclusion Criteria:

• BMI < 27 kg/m²
• Age < 25 and > 65 years
• Pregnant women or women who plan on becoming pregnant during the study
• Postpartum women
• Lactating women
• Diabetes mellitus
• Kidney disease
• Liver disease
• Certain cancers
• Smokers